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ProteomicsPulmonary and Renal Long COVID at Two-year Revisit
To outline the temporal changes of long COVID, we profiled serum proteomes (dataset SP2) and urine proteomes (dataset UP2). The SP2 were measured for 37 patients during the disease (T1), the convalescence (T2), and at the 1-year revisit (T3); the UP2 were measured for 28 patients during the disease ...
ORGANISM(S): Homo Sapiens 
2024-06-04 | PXD027557 |
MetabolomicsExtracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness
The accumulation of acidic metabolic waste products within the tumor microenvironment profoundly inhibits effector functions of tumor-infiltrating lymphocytes (TILs). However, it is unclear whether extracellular-acidosis impacts T cell metabolic fitness and differentiation status. Here, we surprisin...
2023-01-17 | MTBLS6661 | MetaboLights
MetabolomicsTFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with liver cancer. Interestingly, unexpected polymerization of nuclear actin was observed in TFAM-knockdown HCC cells when cytoske...
2022-06-23 | MTBLS4307 | MetaboLights
TranscriptomicsIntegration of developmental and nutritional cues determines timing of female flower opening in cucumber
The timing of flower opening is essential for pollination and thus seed production. Despite flower opening has been a long lasting topic for plant biologists, the underling molecular mechansim remains elusive. Here we used a unique cucumber line ‘6457’ that spontaneously produces super ovary wit...
ORGANISM(S): Cucumis sativus 
2016-07-25 | E-GEOD-76358 | biostudies-arrayexpress
UnknownLong-term open-label vebicorvir for chronic HBV infection: Safety and off-treatment responses.
Not available
S-EPMC10951643 | biostudies-literature
TranscriptomicsNatural Variation and Timing of Stress Responses Promote and Predict Heterosis
Hybrid plants and animals grow larger and more vigorously than the parents, a common phenomenon known as hybrid vigor or heterosis. Heterosis often correlates with the genetic distance between hybridizing parents, but the mechanism for this is largely unknown. We found that genetic distance was corr...
ORGANISM(S): Arabidopsis thaliana 
2015-05-31 | E-GEOD-51578 | biostudies-arrayexpress
ProteomicsSystematic Proteomics Revealed The mechanism of How Long-term Tibetan Buddhist Meditation Enhanced Cardiovascular Protection
The difficulty to obtain data from whom uninterruptedly practice meditation over many years, and lacking of advanced analysis methods significantly hinder the comprehensive understanding of molecular mechanisms underlying meditation. This study aimed to address this issue.Accordingly, we recruited 8...
ORGANISM(S): Homo Sapiens 
2018-09-27 | PXD057418 |
ProteomicsLC-MS/MS EThcD of MERS-CoV and SARS-CoV S N-linked glycopeptides from recombinant spike ectodomains and whole MERS virions
Recent outbreaks of severe acute respiratory syndrome and Middle-East respiratory syndrome along with the threat of a future coronavirus pandemic underscore the importance of finding ways to neutralize these viruses. The trimeric spike transmembrane glycoprotein S mediates entry into host cells and ...
ORGANISM(S): Severe Acute Respiratory Syndrome-related Coronavirus (ncbitaxon:694009) Middle East Respiratory Syndrome-related Coronavirus (ncbitaxon:1335626) 
2020-03-13 | MSV000085097 | MassIVE
UnknownGenomic expansion of Aldh1a1 protects beavers against high metabolic aldehydes from lipid oxidation.
Not available
S-EPMC8656434 | biostudies-literature
TranscriptomicsDigital gene expression profiling of the Phytophthora sojae transcriptome
This experiment contains Phytophthora sojae samples and RNA-seq data from experiment E-GEOD-29561 (https://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-29651/) to understand gene expression during the P. sojae life cycle. The transcriptome of the oomycete plant pathogen Phytophthora sojae was profi...
ORGANISM(S): Phytophthora sojae 
2011-09-01 | E-MTAB-4039 | biostudies-arrayexpress
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