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TranscriptomicsAn Artificial miRNA Against HSPE Suppresses Melanoma Invasion Properties Correlating with a Down-regulation of Chemokines and MAPK Phosphorylation
Heparanase (HPSE) is an endo-beta-glucuronidase that can cleave heparan sulfate proteoglycans within extracellular matrix, basement membrane or on the cellular surface, closely linked with proliferation, migration, invasion and angiogenesis of tumor cells, and has become a hot treatment target in an...
ORGANISM(S): Homo sapiens 
2012-10-27 | E-MEXP-3443 | biostudies-arrayexpress
MetabolomicsThe Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments

Apicomplexan parasite growth and replication relies on nutrient acquisition from host cells, in which intracellular multiplication occurs, yet the mechanisms that underlie the nutrient salvage remain elusive. Numerous ultrastructural studies have documented a plasma membrane invagination with a d...

2023-04-19 | MTBLS7006 | MetaboLights
ProteomicsTime course treatment with Palmitate and thapsigargin of insulinoma INS-1E cells
Time course treatment with 0.4 mM Palmitate and 200 nM thapsigargin of insulinoma INS-1E cells. Timepoints; 0, 4, 16 and 24h in biological duplicates within an iTRAQ 8 set for palmitate and thapsigargin, respectively.
ORGANISM(S): Rattus Rattus (black Rat) 
2020-08-18 | PXD020851 | JPOST Repository
ProteomicsMulti-omics profiling reveals systemic rejuvenation of the aged kidney through senolytic therapy
Cellular senescence is a key driver of kidney aging, leading to functional decline and increased susceptibility to chronic kidney disease. While the senolytic combination of dasatinib and quercetin (D+Q) has shown promise in mitigating age-related pathologies, its long-term effects and underlying mu...
ORGANISM(S): Homo Sapiens 
2026-03-24 | PXD076057 |
TranscriptomicsTranscription profiling of mouse presenilin conditional double knockout cerebral cortex at 6 months old
Gene expression profile of presenilin conditional double knockout cerebral cortex, comparing to control. Age of mice: 6 months
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-1375 | biostudies-arrayexpress
TranscriptomicsAberrantly expressed lncRNAs in Primary Varicose Great Saphenous Veins
LncRNAs are key regulatory molecules involved in a variety of biological process and human diseases. However, the pathological effects of lncRNAs on primary varicose great saphenous veins (GSVs) remain unclear. In this study, we aimed at identifying aberrantly expressed lncRNAs involved in the preva...
ORGANISM(S): Homo sapiens 
2013-10-01 | E-GEOD-51260 | biostudies-arrayexpress
TranscriptomicsIdentifying vitamin C and RA-regulated genes in the J1 mESCs
It has been demonstrated that vitamin C enhances reprogramming efficiency during inducing pluripotent stem cells, however, the underlying mechanisms are not fully understood. To find the downstream target genes of vitamin C and investigate the mechanism of vitamin C on reprogramming promotion, we pe...
ORGANISM(S): Mus musculus 
2014-01-21 | E-GEOD-43405 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human hematopoietic stem cells engrafted into fetal goats
Robust human-goat chimerism was achieved by transplanting human CD34+Lin- cord blood cells into fetal goats. We observed a broad distribution of GFP-marked human cells in non-hematopoietic organs including kidney, muscle, lung, and heart of transplant goats. Various marker techniques indicated that...
ORGANISM(S): Homo sapiens 
2007-07-19 | E-GEOD-1801 | biostudies-arrayexpress
TranscriptomicsIdentification of miRNAs and Their Target Genes in Peach (Prunus persica L.) Using High-Throughput Sequencing and Degradome Analysis
MicroRNAs play critical roles in various biological and metabolic processes. The function of miRNAs has been widely studied in model plants such as Arabidopsis and rice. However, the number of identified miRNAs and related miRNA targets in peach (Prunus persica) is limited. To understand further the...
ORGANISM(S): Prunus persica 
2014-01-01 | E-GEOD-49579 | biostudies-arrayexpress
MetabolomicsInteraction between Cervical Microbiota and Host Gene Regulation in Caesarean Section Scar Diverticulum

Cesarean section scar diverticulum (CSD) has become a formidable obstacle preventing women receiving CS from reproducing. However, the pathogenesis of CSD remains unexplored. In this study, we characterized the cervical microbiota, metabolome and endometrial transcriptome of women with CSD. Based...

2022-07-25 | MTBLS4967 | MetaboLights
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