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ProteomicsIdentification of Long Lived Synaptic Proteins by Comprehensive Proteomic Analysis of Synaptosome Protein Turnover
Memory formation is believed result from changes in synapse strength and structure. While memories may persist for the lifetime of an organism, the proteins and lipids that make up synapses undergo constant turnover with lifetimes from minutes to days. The molecular basis for memory maintenance may ...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2018-03-19 | PXD007156 | Pride
Protein turnover Long lived protein Synaptosome 
TranscriptomicsBAFF and CD4+ T cells are major survival factors for long-lived splenic plasma cells in a B-cell–depletion context
Previous data have suggested that B-cell–depletion therapy may induce the settlement of autoreactive long-lived plasma cells (LLPCs) in the spleen of patients with autoimmune cytopenia. To investigate this process, we used the AID-CreERT2-EYFP mouse model to follow PCs engaged in an immune response....
ORGANISM(S): Mus musculus 
2018-02-19 | E-MTAB-6449 | biostudies-arrayexpress
TranscriptomicsTime-course gene expression profiles of a Saccharomyces cerevisiae wild type and long-lived sch9-delta mutant
The SCH9 null strain has smaller cell size, grows at a slower rate and survives three times longer than wide-type yeast. This study aims to dissect the mechanisms that lead to the yeast life span extension of sch9-delta. We measure gene expression profiles of the S. cerevisiae wild type and the lon...
ORGANISM(S): Saccharomyces cerevisiae 
2009-12-24 | E-GEOD-14227 | biostudies-arrayexpress
ProteomicsLong-lived proteins and DNA as candidate predictive biomarkers for tissue associated diseases
Protein turnover, the result of protein synthesis and degradation, is an important mechanism to preserve cellular integrity. The majority of cellular proteins are broken down over a period of hours to weeks to prevent a buildup of proteins that lose their function due to damage caused by misfolding,...
ORGANISM(S): Mus Musculus 
2024-03-21 | PXD050843 |
ProteomicsIdentification of proteins synthesized from long-lived mRNAs during seed germination in rice
To identify the proteins synthesized from long-lived mRNAs at early phase of germination, proteome of embryos at 0 DAI (dry embryos), 1 DAI with α-amanitin and 1 DAI without α-amanitin were analyzed by using LC-MS/MS.
ORGANISM(S): Oryza sativa (Rice) 
2019-08-13 | PXD013628 | Pride
Α-amanitin Imbibition Embryo Rice 
TranscriptomicsTranscription profiling of long-lived Ames dwarf mice investigating the loss of liver sexual dimorphism
Gender-specific alterations in gene expression and loss of liver sexual dimorphism in the long-lived Ames dwarf mice.
ORGANISM(S): Mus musculus 
2005-05-30 | E-MEXP-347 | biostudies-arrayexpress
ProteomicsIdentification of long-lived proteins in the mitochondria reveals increased stability of the electron transport chain
In order to combat molecular damage, most cellular proteins undergo rapid turnover. We have previously identified large nuclear protein assemblies that can persist for years in post-mitotic tissues and are subject to age-related decline. Here we report that mitochondria can be long-lived in the mous...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-11-04 | PXD028963 | Pride
Mitochondria  protein homeostasis  long-lived proteins  electron transport chain 
TranscriptomicsmiRNA Profiles of Long-Lived Individuals (>=90 years)
This project analyzes peripheral blood profiles of patients of age 90 or above and aims to detect profiles that distinguish them from younger controls. n = 55 normal controls and n = 15 long lived individuals have been screened for the complete miRNA repertoire. Please note that each miRNA has been ...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-27905 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of long-lived C.elegans daf-2 pathway mutants with wild type/short-lived mutants
Comparison of long-lived daf-2 pathway mutants with wild type/short-lived mutants. A: age-1 fer-15; fem-1 vs. fer-15; fem-1. B: age-1 fer-15; fem-1 vs. fer-15; fem-1. C: fer-15; daf-2(mu150); fem-1 vs. fer-15; fem-1. D: fer-15; daf-2(mu150); fem-1 vs. fer-15; fem-1. E: daf-16::gfp in daf...
ORGANISM(S): Caenorhabditis elegans 
2003-07-17 | E-MEXP-7 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse long-lived S6K1 -/- strain females compared to wild types
We examined the transcript changes in long-lived S6K1-/- female mice compared to wild type controls.
ORGANISM(S): Mus musculus 
2009-09-04 | E-MEXP-2320 | biostudies-arrayexpress
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