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GenomicsPrep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis.
Prep1 is a tumor-suppressor, whereas Meis1 is an oncogene. We show that to perform these activities in MEFs both proteins competitively hetero-dimerize with Pbx1. Meis1 alone transforms Prep1-deficient fibroblasts while Prep1 overexpression inhibits Meis1 tumorigenicity. Pbx1 can therefore alternati...
ORGANISM(S): Mus musculus 
2014-03-05 | E-GEOD-54221 | biostudies-arrayexpress
GenomicsPrep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis [hP]
Prep1 is a tumor-suppressor, whereas Meis1 is an oncogene. We show that to perform these activities in MEFs both proteins competitively hetero-dimerize with Pbx1. Meis1 alone transforms Prep1-deficient fibroblasts while Prep1 overexpression inhibits Meis1 tumorigenicity. Pbx1 can therefore alternati...
ORGANISM(S): Mus musculus 
2016-06-01 | E-GEOD-58802 | biostudies-arrayexpress
UnknownPresence and infectivity of SARS-CoV-2 virus in wastewaters and rivers.
Not available
S-EPMC7358170 | biostudies-literature
UnknownAutoantibodies identify primary Sjogren's syndrome in patients lacking serum IgG specific for Ro/SS-A and La/SS-B.
Not available
S-EPMC10546962 | biostudies-literature
UnknownReplacing Manual Planning of Whole Breast Irradiation With Knowledge-Based Automatic Optimization by Virtual Tangential-Fields Arc Therapy.
Not available
S-EPMC8423088 | biostudies-literature
UnknownChanges in Bull Semen Metabolome in Relation to Cryopreservation and Fertility.
Not available
S-EPMC7341314 | biostudies-literature
UnknownPlasma Small Extracellular Vesicle Cathepsin D Dysregulation in GRN/C9orf72 and Sporadic Frontotemporal Lobar Degeneration.
Not available
S-EPMC9504770 | biostudies-literature
UnknownDown syndrome fibroblasts and mouse Prep1-overexpressing cells display increased sensitivity to genotoxic stress.
Not available
S-EPMC2887940 | biostudies-literature
UnknownAssociation of Increased Serum Lipopolysaccharide, But Not Microbial Dysbiosis, With Obesity-Related Osteoarthritis.
Not available
S-EPMC8795472 | biostudies-literature
TranscriptomicsmicroRNA expression in rat lung receiving chemopreventive agents and attenuation of cigarette smoke-induced alterations
We previously showed that exposure of rats to environmental cigarette smoke (ECS) causes extensive downregulation of microRNA expression in the lung, resulting in overexpression of multiple genes and proteins. In the present study, we evaluated by microarray the expression of 484 microRNAs in the l...
ORGANISM(S): Rattus norvegicus 
2010-05-16 | E-GEOD-19540 | biostudies-arrayexpress
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