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MetabolomicsPeripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
UnknownProtein kinase C-theta (PKCθ) phosphorylates and inhibits the guanine exchange factor, GIV/Girdin.
Not available
S-EPMC3619294 | biostudies-literature
UnknownGIV/Girdin activates Gαi and inhibits Gαs via the same motif.
Not available
S-EPMC5047194 | biostudies-literature
UnknownUnderstanding Discontinuation Rates and Acceptance of the Low-Dose Levonorgestrel Intrauterine System in Spain: A Comprehensive Analysis of Bleeding Patterns and Influencing Factors.
Not available
S-EPMC11931107 | biostudies-literature
UnknownSurvival impact of previous statin therapy in patients hospitalized with COVID-19.
Not available
S-EPMC9726688 | biostudies-literature
UnknownSurvival impact of previous statin therapy in patients hospitalized with COVID-19.
Not available
S-EPMC9080058 | biostudies-literature
ProteomicsDevelopment of novel chemical inhibitors of SETD8
SETD8 is a histone methyltransferase that catalyzes the monomethylation of histone H4K20. Overexpressed in cancer, several studies have suggested that it could be a potential target for treatment in certain tumors. However, there are currently very few SETD8 inhibitors, and all of them have bad phar...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD051199 | Pride
Drug targets Thermal proteoome profiling Cancer 
UnknownA Phase III Randomized Controlled Trial of Plitidepsin, a Marine-Derived Compound, in Hospitalized Adults With Moderate COVID-19.
Not available
S-EPMC11478586 | biostudies-literature
UnknownIn Vitro Antifungal Activity of Ibrexafungerp (SCY-078) Against Contemporary Blood Isolates From Medically Relevant Species of Candida: A European Study.
Not available
S-EPMC9149255 | biostudies-literature
UnknownResuscitation fluid practices in Brazilian intensive care units: a secondary analysis of Fluid-TRIPS.
Not available
S-EPMC8275089 | biostudies-literature
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