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UnknownHeterozygous BTNL8 variants in individuals with multisystem inflammatory syndrome in children (MIS-C).
Multisystem inflammatory syndrome in children (MIS-C) is a rare condition following SARS-CoV-2 infection associated with intestinal manifestations. Genetic predisposition, including inborn errors of the OAS-RNAseL pathway, has been reported. We sequenced 154 MIS-C patients and utilized a novel stati...
S-EPMC11586762 | biostudies-literature
UnknownFecal immunochemical test accuracy in average-risk colorectal cancer screening.

Aim

To assess the fecal immunochemical test (FIT) accuracy for colorectal cancer (CRC) and advanced neoplasia (AN) detection in CRC screening.

Methods

We performed a multicentric, prospective, double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to...
S-EPMC3921527 | biostudies-literature
UnknownIvermectin compared with placebo in the clinical course in Mexican patients with asymptomatic and mild COVID-19: a randomized clinical trial.

Background

Despite the development and application of vaccines against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) around the world, the scientific community is still trying to find some therapies to avoid or ameliorate the fatal evolution of the Coronavirus disease 2019 (CO...
S-EPMC9730611 | biostudies-literature
UnknownChanges in the Brain Extracellular Matrix Composition in schizophrenia: A Pathophysiological Dysregulation and a Potential Therapeutic Target.
The brain extracellular matrix (ECM) is involved in crucial processes of neural support, neuronal and synaptic plasticity, extrasynaptic transmission, and neurotransmission. ECM is a tridimensional fibrillary meshwork composed of macromolecules that determine its bioactivity and give it unique chara...
S-EPMC11421689 | biostudies-literature
UnknownDeploying unsupervised clustering analysis to derive clinical phenotypes and risk factors associated with mortality risk in 2022 critically ill patients with COVID-19 in Spain.

Background

The identification of factors associated with Intensive Care Unit (ICU) mortality and derived clinical phenotypes in COVID-19 patients could help for a more tailored approach to clinical decision-making that improves prognostic outcomes.

Methods

Prospective, multicenter, ob...
S-EPMC7883885 | biostudies-literature
UnknownInterferon γ selectively promotes survival of alveolar progenitor cells in a human lung organoid model
Disease of the lung alveoli is frequently associated with acute or chronic inflammation. At present, there are no effective therapies to support regeneration of the alveolar epithelium, and ongoing inflammation adds an additional layer of complexity to many lung diseases. Here, we describe a primary...
S-SCDT-10_1038-S44318-026-00774-4 | biostudies-other
UnknownValidation of the RIM Score-COVID in the Spanish SEMI-COVID-19 Registry.
The significant impact of COVID-19 worldwide has made it necessary to develop tools to identify patients at high risk of severe disease and death. This work aims to validate the RIM Score-COVID in the SEMI-COVID-19 Registry. The RIM Score-COVID is a simple nomogram with high predictive capacity for ...
S-EPMC9862219 | biostudies-literature
UnknownHigh-dose vitamin D versus placebo to prevent complications in COVID-19 patients: Multicentre randomized controlled clinical trial.

Background

The role of oral vitamin D3 supplementation for hospitalized patients with COVID-19 remains to be determined. The study was aimed to evaluate whether vitamin D3 supplementation could prevent respiratory worsening among hospitalized patients with COVID-19.

Methods and findings

S-EPMC9140264 | biostudies-literature
UnknownA Phase III Randomized Controlled Trial of Plitidepsin, a Marine-Derived Compound, in Hospitalized Adults With Moderate COVID-19.

Background

Plitidepsin has shown potent preclinical activity against severe acute respiratory syndrome coronavirus 2 and was generally well tolerated in a phase I trial of hospitalized patients with coronavirus disease 2019 (COVID-19). NEPTUNO, a phase III, multicenter, randomized, controlle...
S-EPMC11478586 | biostudies-literature
UnknownRemdesivir and survival outcomes in critically ill patients with COVID-19: A multicentre observational cohort study.
Not available
S-EPMC9804970 | biostudies-literature
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