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ProteomicsA lineage master regulator and cancer-selective partner transcription factor reprogram 3D chromatin topology to establish tumor-specific gene control
Lineage-determining transcription factors (TFs), such as p63 in epithelial tissues, establish normal tissue identity but can also drive carcinogenesis. The epigenetic basis for these divergent effects, however, is unclear. Here, we show that p63 reorganizes three-dimensional (3D) chromatin topology ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD073599 | Pride
P63 foxk1 
ProteomicsGlucose modulates transcription factor dimerization to enable tissue differentiation
Glucose is a universal energy currency for living organisms, however, its non-energetic functions in processes such as differentiation are undefined. In epidermis, differentiating cells exhibit dynamic changes in gene expression1-4 driven by specific transcription factors (TFs)5-9. The interplay bet...
ORGANISM(S): Homo sapiens (Human) 
2025-03-13 | PXD038128 | Pride
Differentiation Metabolomics Glucose Irf6 
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