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TranscriptomicsTranscription profiling of skin from interferon regulatory factor 6 (Irf6) knockout mice and wild type mice to study the role for Irf6 in epidermal development.
Transcription factor paralogs may share a common role (e.g. Hox) in staged or overlapping expression in specific tissues. In other examples, members have distinct roles in a range of embryologic, differentiation or response pathways (e.g. Tbx, Pax). For the Interferon Regulatory Factor (IRF) famil...
ORGANISM(S): Mus musculus 
2007-11-13 | E-GEOD-5800 | biostudies-arrayexpress
ProteomicsInterferon Regulatory Factor 6 (IRF6) knockout in human keratinocytes disrupts epithelial homeostasis
The transcription factor Interferon Regulatory Factor 6 (IRF6) is crucially involved in craniofacial development and regulates the proliferation/differentiation balance in keratinocytes. Pathological IRF6 variants have been found in Van der Woude syndrome (VWS), the most common syndromic form of cle...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027669 | Pride
Cell-cell contacts Oral mucosa Proteomics Skin Differentiation Irf6 
ProteomicsGlucose modulates transcription factor dimerization to enable tissue differentiation
Glucose is a universal energy currency for living organisms, however, its non-energetic functions in processes such as differentiation are undefined. In epidermis, differentiating cells exhibit dynamic changes in gene expression1-4 driven by specific transcription factors (TFs)5-9. The interplay bet...
ORGANISM(S): Homo sapiens (Human) 
2025-03-13 | PXD038128 | Pride
Differentiation Metabolomics Glucose Irf6 
GenomicsRNAseq E15.5 mouse skin WT, Irf6 KO, Ripk4 KD, and Irf6 S413A.S424A knockin
RNAseq E15.5 mouse skin WT, Irf6 KO, Ripk4 KD, and Irf6 S413A.S424A knockin
PRJNA510610 | ENA
GenomicsIrf6 wildtype and knock out ATAC-seq
Irf6 wildtype and knock out ATAC-seq
PRJNA524711 | ENA
GenomicsIrf6 wildtype and knock out ChIP-seq
Irf6 wildtype and knock out ChIP-seq
PRJNA524709 | ENA
GenomicsRNAseq E16.5 mouse skin Irf6 KO vs WT
RNAseq E16.5 mouse skin Irf6 KO vs WT
PRJNA510612 | ENA
GenomicsEmbryonic transcriptome analysis of wt vs irf6-/- zebrafish at 4hpf
Embryonic transcriptome analysis of wt vs irf6-/- zebrafish at 4hpf
PRJNA644319 | ENA
TranscriptomicsRNAseq E15.5 mouse skin WT, Irf6 KO, Ripk4 KD, and Irf6 S413A.S424A knockin
The integrity of the mammalian epidermis is essential for organism survival, and it depends on a balance of proliferation and differentiation in the resident stem cell population. The kinase Ripk4 and the transcription factor Irf6 are mutated in severe developmental syndromes in humans, and mice lac...
ORGANISM(S): Mus musculus 
2019-08-29 | GSE124047 | GEO
UnknownIRF6 expression in basal epithelium partially rescues Irf6 knockout mice.
Not available
S-EPMC5552062 | biostudies-literature
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