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TranscriptomicsAkt signalling leads to stem cell activation and promotes tumour development in epidermis.
A permantly active form of the oncogene Akt was expressed in the keratinocytes of the basal proliferative layer of the epidermis. Stem cells of the hair follicle expressing the cell surface marker CD34 were isolated. RNA form the CD34(+) and CD34(-) keratinocytes was extracted and and hybridized to ...
ORGANISM(S): Mus musculus 
2014-01-26 | E-GEOD-48522 | biostudies-arrayexpress
TranscriptomicsE2F1 loss induces spontaneous tumour development in Rb-deficient epidermis
The specific ablation of Rb1 gene in epidermis (RbF/F;K14cre) promotes proliferation and altered differentiation but does not produce spontaneous tumour development. These phenotypic changes are associated with increased expression of E2F members and E2F-dependent transcriptional activity. Here, we ...
ORGANISM(S): Mus musculus 
2012-08-20 | E-GEOD-38048 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy (testing dataset)
The epidermal specific ablation of Trp53 gene leads to the spontaneous development of aggressive tumors in mice through a process that is accelerated by the simultaneous ablation of Rb gene. Since alterations of p53-dependent pathway are common hallmarks of aggressive, poor prognostic human cancers,...
ORGANISM(S): Mus musculus 
2010-07-20 | E-GEOD-19616 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy (training dataset)
The epidermal specific ablation of Trp53 gene leads to the spontaneous development of aggressive tumors in mice through a process that is accelerated by the simultaneous ablation of Rb gene. Since alterations of p53-dependent pathway are common hallmarks of aggressive, poor prognostic human cancers,...
ORGANISM(S): Mus musculus 
2010-07-20 | E-GEOD-11990 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse stratified epithelial spontaneous SCC induced by the somatic inactivation of Rb1 and Trp53 tumor suppressors
The squamous cell carcinomas represent the aggressive type of non melanoma skin cancer, the most frequent malignancy among human population. We have studied here the possible relationship between these two pathways in skin using epidermal-specific mutant mice. Loss of p53, but not pRb, produces spon...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9144 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse whole skin from pRB deficient animals reveals that p107 acts as a tumor suppressor
The specific deletion of Rb gene in epidermis leads to altered proliferation and differentiation, but not to the development of spontaneous tumors. Our previous data have demonstrated the existence of a functional compensation of Rb loss by Rbl1 (p107) in as the phenotypic differences with respect t...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9567 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse epidermis from Rb(F19/F19)K14cre;Rbl2-/- (pRb-;p130-) mutants to analyse functional redundancies between retinoblastoma family members
The epidermal-specific ablation of Rb gene leads to increased proliferation, aberrant differentiation, and the disengagement of these processes in vivo and in vitro. These differences in phenotype are more severe with the loss of p107, demonstrating the functional compensation between pRb and p107. ...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9562 | biostudies-arrayexpress
TranscriptomicsA Functional Role of RB-Dependent Pathway in the Control of Quiescence in Adult Epidermal Stem Cells Revealed by Genomic Profiling
Continuous cell renewal in mouse epidermis is at the expense of a pool of pluripotent cells that lie in a well defined niche in the hair follicle known as the bulge. To identify mechanisms controlling hair follicle stem cell homeostasis, we developed a strategy to isolate adult bulge stem cells in m...
ORGANISM(S): Mus musculus 
2010-03-20 | E-GEOD-19448 | biostudies-arrayexpress
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