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UnknownEffects of combination lipid therapy in type 2 diabetes mellitus.

Background

We investigated whether combination therapy with a statin plus a fibrate, as compared with statin monotherapy, would reduce the risk of cardiovascular disease in patients with type 2 diabetes mellitus who were at high risk for cardiovascular disease.

Methods

We randomly ass...
S-EPMC2879499 | biostudies-literature
UnknownEffects of intensive glucose lowering in type 2 diabetes.

Background

Epidemiologic studies have shown a relationship between glycated hemoglobin levels and cardiovascular events in patients with type 2 diabetes. We investigated whether intensive therapy to target normal glycated hemoglobin levels would reduce cardiovascular events in patients with ...
S-EPMC4551392 | biostudies-literature
UnknownEffects of intensive blood-pressure control in type 2 diabetes mellitus.

Background

There is no evidence from randomized trials to support a strategy of lowering systolic blood pressure below 135 to 140 mm Hg in persons with type 2 diabetes mellitus. We investigated whether therapy targeting normal systolic pressure (i.e., <120 mm Hg) reduces major cardiovascular...
S-EPMC4123215 | biostudies-literature
UnknownEffect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial.

Background

Hyperglycaemia is associated with increased risk of cardiovascular complications in people with type 2 diabetes. We investigated whether reduction of blood glucose concentration decreases the rate of microvascular complications in people with type 2 diabetes.

Methods

ACCORD...
S-EPMC4123233 | biostudies-literature
UnknownLong-term effects of intensive glucose lowering on cardiovascular outcomes.

Background

Intensive glucose lowering has previously been shown to increase mortality among persons with advanced type 2 diabetes and a high risk of cardiovascular disease. This report describes the 5-year outcomes of a mean of 3.7 years of intensive glucose lowering on mortality and key car...
S-EPMC4083508 | biostudies-literature
UnknownFinal Report of a Trial of Intensive versus Standard Blood-Pressure Control.

Background

In a previously reported randomized trial of standard and intensive systolic blood-pressure control, data on some outcome events had yet to be adjudicated and post-trial follow-up data had not yet been collected.

Methods

We randomly assigned 9361 participants who were at in...
S-EPMC9907774 | biostudies-literature
UnknownAssociation of Intensive vs Standard Blood Pressure Control With Magnetic Resonance Imaging Biomarkers of Alzheimer Disease: Secondary Analysis of the SPRINT MIND Randomized Trial.

Importance

Meta-analyses of randomized clinical trials have indicated that improved hypertension control reduces the risk for cognitive impairment and dementia. However, it is unclear to what extent pathways reflective of Alzheimer disease (AD) pathology are affected by hypertension control....
S-EPMC7941253 | biostudies-literature
UnknownEffects of medical therapies on retinopathy progression in type 2 diabetes.

Background

We investigated whether intensive glycemic control, combination therapy for dyslipidemia, and intensive blood-pressure control would limit the progression of diabetic retinopathy in persons with type 2 diabetes. Previous data suggest that these systemic factors may be important in...
S-EPMC4026164 | biostudies-literature
UnknownIncorporating Concomitant Medications into Genome-Wide Analyses for the Study of Complex Disease and Drug Response.
Given the high costs of conducting a drug-response trial, researchers are now aiming to use retrospective analyses to conduct genome-wide association studies (GWAS) to identify underlying genetic contributions to drug-response variation. To prevent confounding results from a GWAS to investigate drug...
S-EPMC5013254 | biostudies-literature
UnknownKidney Disease, Hypertension Treatment, and Cerebral Perfusion and Structure.

Rationale & objective

The safety of intensive blood pressure (BP) targets is controversial for persons with chronic kidney disease (CKD). We studied the effects of hypertension treatment on cerebral perfusion and structure in individuals with and without CKD.

Study design

Neuroimaging...
S-EPMC8926938 | biostudies-literature
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