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MetabolomicsVitamin D deficiency disrupts a host–microbiota bile acid axis in aged mice to drive Faecalibaculum rodentium expansion and intestinal epithelial barrier dysfunction
This study investigated how vitamin D deficiency alters the fecal metabolome and bile acid metabolism in mice and evaluated the contribution of Faecalibaculum rodentium bile salt hydrolase activity to intestinal epithelial barrier dysfunction. Two complementary mouse experiments were included. In th...
2026-08-07 | MTBLS15279 | MetaboLights
MetabolomicsFecal short-chain fatty acids in DSS-induced colitis mice treated with a D-lactate-free probiotic
Targeted GC-MS quantification of short- and branched-chain fatty acids in feces of C57BL/6J (B6J-UniBe) mice with acute dextran sulfate sodium (DSS)-induced colitis. Mice received the D-lactate-free probiotic consortium Pro4-50 by daily oral gavage either from the start of the experiment (Pre, n=10)...
2026-10-08 | MTBLS15952 | MetaboLights
MetabolomicsBenchmark datasets for 3D MALDI- and DESI-Imaging Mass Spectrometry
Three-dimensional imaging mass spectrometry (3D imaging MS) is a technique of analytical chemistry for 3D molecular analysis of a tissue specimen, entire organ, or microbial colonies on an agar plate. 3D imaging MS has unique advantages over existing 3D imaging techniques, offers novel perspectives ...
2016-07-27 | MTBLS176 | MetaboLights
MetabolomicsA Transferable Workflow for Confident Annotation of Polar Analytes in 4D-Metabolomics
Introduction High-confidence annotation of polar metabolites remains a central challenge in non-targeted metabolomics. While derivatization improves chromatographic retention and ionization of derivatized compounds, it changes the molecules, making annotation using conventional annotation workflows ...
2026-10-19 | MTBLS16057 | MetaboLights
Metabolomics3D DESI mass spectrometry imaging of 51 serial sections from a human liver metastasis
51 serial sections from a single human liver metastasis are made available in this dataset. Four neighbouring sections were placed on a single slide and analysed together. The tissue sections were analysed by desorption electrospray ionisation mass spectrometry imaging (DESI-MSI) according to the pr...
2016-04-28 | MTBLS282 | MetaboLights
MetabolomicsGlutamine-restricted diets restore sensitivity to KRASG12D inhibitor through the reversal of ANXA1-mediated metabolic reprogramming
This study investigates the mechanisms underlying KRASG12D inhibitor resistance and evaluates strategies to enhance treatment sensitivity. Our findings indicate that a glutamine-restricted diet not only reverses KRASG12D inhibitor resistance in PDAC but also achieves durable remission with long-term...
2026-06-27 | MTBLS14825 | MetaboLights
MetabolomicsFoHsf1 reprograms central metabolism via caffeine and vitamin D2 to modulate development and virulence of Fusarium oxysporum on Polygonatum kingianum
Root rot has severely affected the yield and quality of Polygonatum kingianum, and Fusarium oxysporum has been identified as the primary causal agent. To explore the virulence mechanisms of this pathogen, we performed a functional characterization of FoHsf1, a gene encoding a heat shock transcriptio...
2026-04-11 | MTBLS14221 | MetaboLights
TranscriptomicsTranscriptional comparison of the filamentous fungus Neurospora crassa growing on three major monosaccharides D-glucose, D-xylose and L-arabinose
D-glucose, D-xylose and L-arabinose are three major monosaccharides in the plant cell wall. Complete utilization of all three sugars is still a bottleneck for second-generation cellulolytic bioethanol production, especially for L-arabinose. However, little is known about the gene expression profiles...
ORGANISM(S): Neurospora crassa 
2014-03-17 | E-GEOD-51091 | biostudies-arrayexpress
MetabolomicsLow-temperature induced neuro-oxidative stress and metabolic reprogramming in the brain of juvenile fourfinger threadfin (Eleutheronema tetradactylum)
This study investigated the effects of low-temperature stress on the brain metabolome of juvenile fourfinger threadfin (Eleutheronema tetradactylum). Using UHPLC-Q-TOF-MS-based untargeted metabolomics, we analyzed brain tissues from fish exposed to 28°C (control) and 18°C for 7 and 14 days. The aim ...
2026-07-22 | MTBLS15103 | MetaboLights
TranscriptomicsExpression data from brain tissue of Rattus norvegicus treated with D-Serine
d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxi...
ORGANISM(S): Rattus norvegicus 
2008-03-08 | E-GEOD-10748 | biostudies-arrayexpress
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