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MetabolomicsProtein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spectrometry integrated with equilibrium dialysis for the disco...

2023-08-07 | MTBLS7237 | MetaboLights
Metabolomics3D'omics: Mannan fibre swine trial & Protein digestibility swine trial

Mannan fibre swine trial, BioProject PRJEB86261 at https://www.ebi.ac.uk/ena/browser/view/PRJEB86261

Protein digestibility swine trial, BioProject PRJEB86262 at https://www.ebi.ac.uk/ena/browser/view/PRJEB86262



2025-12-19 | MTBLS13348 | MetaboLights
MetabolomicsMetabolomic Discrimination of Near Isogenic Low and High Phytate Soybean Seeds
Methodologies for untargeted metabolomic profiling using liquid chromatography-mass spectrometry (LC-MS) were developed and applied to lipid-depleted methanolic extracts of soybeans seeds obtained from four near isogenic soybean lines (NILs) that differed in phytate content. The four lines differed ...
2016-02-04 | MTBLS120 | MetaboLights
MetabolomicsPlasma non-targeted metabolome of high- and low-body-weight broilers

In large-scale poultry farming, broilers of the same breed share a common genetic background and identical management conditions, yet substantial individual variation in body weight persists. In this study, we identified distinct plasma proteomic profiles between high and low weight broilers, wit...

2025-06-10 | MTBLS12390 | MetaboLights
MetabolomicsOral administration of low-molecular-weight heparin ameliorates colitis by enhancing the gut mucus barrier via microbial tryptophan metabolites

Background and Purpose: Previous studies have reported that oral low molecular weight heparin (LMWH) ameliorated colitis by undefined mechanisms in ulcerative colitis (UC) patients. Our study explored the mechanisms of LMWH on colitis from the perspective of gut microbiota and its metabolites.

2025-10-12 | MTBLS5770 | MetaboLights
MetabolomicsFatty acid transport protein 4 is required for incorporation of saturated ultralong-chain fatty acids into epidermal ceramides and monoacylglycerols
Fatty acid transport protein 4 (FATP4) is an acyl-CoA synthetase that is required for normal permeability barrier in mammalian skin. FATP4 (SLC27A4) mutations cause ichthyosis prematurity syndrome, a nonlethal disorder. In contrast, Fatp4-/- mice die neonatally from a defective barrier. H...
2021-07-15 | MTBLS1138 | MetaboLights
MetabolomicsCircadian disruption exacerbates MASH in mice by reducing intestinal Akkermansia muciniphila abundance via the FXR-CYP7A1-bile acid axis_Targeting Bile Acids_Untargeted Serum Metabolomics

Circadian disruption has emerged as a significant public health issue and is increasingly recognized as a contributor to the progression of metabolic dysfunction-associated steatotic liver disease (MASLD), though the underlying mechanisms remain poorly understood. In this study, we established a ...

2026-02-05 | MTBLS13848 | MetaboLights
ProteomicsLow-Abundance Serum Protein Biomarker Candidates for HCC in Patients with Liver Cirrhosis
In this study, we employed both untargeted and targeted analysis of low abundance serum proteins to identify potential biomarkers for HCC. We employed a two-phase proteomics approach to identify low abundance serum proteins as potential biomarkers for HCC.The first phase involved DDA-based untargete...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD061721 | Pride
Nano-lc-ms/ms Low abundance protein Serum Liliver cancer Biomarker 
TranscriptomicsAnnotating Low Abundance and Transient RNAs in Yeast using Ultra High-throughput Sequencing
Annotating Low Abundance and Transient RNAs in Yeast using Tiling Microarrays and Ultra High-throughput Sequencing Reveals New Transcripts that are not Conserved Across Closely Related Yeast Species A complete description of the transcriptome of an organism is crucial for a comprehensive understand...
ORGANISM(S): Saccharomyces cerevisiae 
2008-12-18 | E-GEOD-11801 | biostudies-arrayexpress
MetabolomicsPhysiological, Transcriptomic, and Metabolomic Insights into Ammonia-Nitrogen Stress in the Hepatopancreas of Litopenaeus vannamei Acclimated to Low Salinity
High ammonia nitrogen stress markedly decreases the survival rate of Litopenaeus vannamei under low-salinity conditions. Nevertheless, most available studies have primarily focused on the ammonia nitrogen response of small-sized shrimp under single-stressor exposure or normal seawater salinity. The ...
2026-08-13 | MTBLS14736 | MetaboLights
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