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ProteomicsSurface proteome profiling of p53-restorable murine liver cancer cells
Characterization of the surface proteome changes between proliferating and senescent liver cancer cells induced by p53 restoration.
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD034465 | Pride
Surface proteome P53 restoration Liver cancer Senescence 
GenomicsH3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence (ChIP-seq)
Cellular senescence is a tumor-suppressive program that involves chromatin reorganization and specific changes in gene expression that trigger an irreversible cell-cycle arrest. We combined quantitative mass spectrometry and ChIP deep-sequencing to identify changes in histone modification occurring ...
ORGANISM(S): Homo sapiens 
2013-01-31 | E-GEOD-43921 | biostudies-arrayexpress
TranscriptomicsH3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence (expression)
Cellular senescence is a tumor-suppressive program that involves chromatin reorganization and specific changes in gene expression that trigger an irreversible cell-cycle arrest. We have examined the effect of suppressing the histone demethylases Jarid1a and Jarid1b on the senescence-associated gene ...
ORGANISM(S): Homo sapiens 
2013-01-31 | E-GEOD-43920 | biostudies-arrayexpress
GenomicsGenome-wide analysis of RB and p130 binding in human diploid fibroblasts
The action of RB as a tumor suppressor has been difficult to define, in part, due to the redundancy of the related proteins p107 and p130. By coupling advanced RNAi technology with a genome wide analysis of gene expression and RB chromatin binding, we identified a unique and specific activity of RB ...
ORGANISM(S): Homo sapiens 
2010-01-15 | E-GEOD-19898 | biostudies-arrayexpress
TranscriptomicsExpression data from either growing IMR90 human fibroblasts or senescent IMR90 cells with Ras expression and indicated hairpins
Oncogene-induced senescence is an anti-proliferative stress response program that acts as a fail-safe mechanism to limit oncogenic transformation and is regulated by the retinoblastoma protein (RB) and p53 tumor suppressor pathways. We identify the atypical E2F family member E2F7 as the only E2F t...
ORGANISM(S): Homo sapiens 
2012-08-25 | E-GEOD-40349 | biostudies-arrayexpress
Proteomics,MultiomicsIdentification SETD1A-binding proteins by Co-IP MS
The dataset contains the gelLC MS analysis of immunoprecipitated complex from full-lenght and truncated SETD1A. The protein was ectopically expressed and the binders immunoprecipitated in cell transduced with the empty vector were analyzed as control.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-08-01 | MSV000080012 | MassIVE
TranscriptomicsRNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukemia
Epigenetic pathways regulate gene expression by controlling and interpreting chromatin modifications. Cancer cells are characterized by altered epigenetic landscapes and commonly exploit the chromatin regulatory machinery to enforce oncogenic gene expression programs. While chromatin alterations are...
ORGANISM(S): Homo sapiens 
2011-08-03 | E-GEOD-29799 | biostudies-arrayexpress
TranscriptomicsMutant p53 Disrupts Mammary Acinar Morphogenesis via the Mevalonate Pathway
p53 is a frequent target for mutation in human tumors and previous studies have revealed that these missense mutant proteins can actively contribute to tumorigenesis. To elucidate how mutant p53 might contribute to mammary carcinogenesis we employed a three-dimensional (3D) culture model. In 3D cul...
ORGANISM(S): Homo sapiens 
2012-02-13 | E-GEOD-31812 | biostudies-arrayexpress
Genomicsena-DATASET-MGH-10-02-2015-15:17:58:985-1 - samples
DNA was derived from the primary tumour, lung metastasis, and peri-aortic lymph node metastasis. DNA from the spleen was used as a normal control. For WE sequencing we user Hybrid capture (Nimblegen version 3.0) of the lymph node and lung metastases, primary tumour and spleen normal; we generated ~1...
EGAD00001001252 | EGA
Genomicsena-DATASET-MGH-10-02-2015-15:19:45:352-2 - samples
DNA was derived from the primary tumour, lung metastasis, and peri-aortic lymph node metastasis. DNA from the spleen was used as a normal control. WG sequencing produced ~30-fold (primary tumour, spleen normal)-50-fold (lung metastasis) coverage
EGAD00001001253 | EGA
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