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TranscriptomicsTranscriptional profiling of bulge stem cells
In adult skin, each hair follicle contains a reservoir of stem cells (the bulge), which can be mobilized to regenerate the new follicle with each hair cycle and to reepithelialize epidermis during wound repair. Here we report new methods that permit their clonal analyses and engraftment and demonstr...
ORGANISM(S): Mus musculus 
2012-10-19 | E-GEOD-41704 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human late passage hiPSCs (pluripotent stem cells)
Detailed analysis comparing induced pluripotent stem cells revealed functional gene expression differences to hESCs that are changed with long term passaging. We used microarrays to detail the changes that are made throughout passaging to hiPSC lines. Experiment Overall Design: hiPSC lines were harv...
ORGANISM(S): Homo sapiens 
2009-07-19 | E-GEOD-16654 | biostudies-arrayexpress
TranscriptomicsDefining the role of oxygen tension in human neural progenitor fate
Hypoxia augments human embryonic stem cell self-renewal via hypoxia-inducible factor 2M-NM-1 (HIF2M-NM-1) activated OCT4 (POU5F1) transcription. Hypoxia also increases the efficiency of reprogramming differentiated cells to a pluripotent-like state. Combined, these findings suggest that low oxygen (...
ORGANISM(S): Homo sapiens 
2014-09-30 | E-GEOD-61842 | biostudies-arrayexpress
GenomicsDynamic Distribution of Linker Histone H1.5 in Cellular Differentiation
Linker histones are essential components of chromatin but the distributions and functions of many during cellular differentiation is not well understood. Here, we show that H1.5 binds to genic and intergenic regions, forming blocks of enrichment, in differentiated human cells from all three embryoni...
ORGANISM(S): Homo sapiens 
2012-12-11 | E-GEOD-26967 | biostudies-arrayexpress
TranscriptomicsGene expression profile of H1 human embryonic stem cells, IMR90 lung fibroblasts, calcium induced keratinocytes, and primary hepatocytes
In humans, there are eleven subtypes of linker histones that exhibit cell- and tissue-specific expression. Linker histone H1 proteins bind to both the core histones and linker DNA of chromatin fibers; and not only participate in control of gene activity but also serve to stabilize higher order chrom...
ORGANISM(S): Homo sapiens 
2012-09-18 | E-GEOD-26855 | biostudies-arrayexpress
TranscriptomicsGene expression profile of H1.5 knockdown and SIRT1 knockdown IMR90 cells versus control cells
In humans, there are eleven subtypes of linker histones that exhibit cell- and tissue-specific expression. Linker histone H1 proteins bind to both the core histones and linker DNA of chromatin fibers; and not only participate in control of gene activity but also serve to stabilize higher order chrom...
ORGANISM(S): Homo sapiens 
2012-09-18 | E-GEOD-26856 | biostudies-arrayexpress
TranscriptomicsDynamic Distribution of Linker Histone H1.5 in Cellular Differentiation
Linker histones are essential components of chromatin but the distributions and functions of many during cellular differentiation is not well understood. Here, we show that H1.5 binds to genic and intergenic regions, forming blocks of enrichment, in differentiated human cells from all three embryoni...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-41761 | biostudies-arrayexpress
UnknownNovel loci for childhood body mass index and shared heritability with adult cardiometabolic traits.
Not available
S-EPMC7581004 | biostudies-literature
UnknownProspects for observing and localizing gravitational-wave transients with Advanced LIGO, Advanced Virgo and KAGRA.
Not available
S-EPMC5920066 | biostudies-literature
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