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TranscriptomicsTranscriptomic survey of lymph node-positive vs. - negative ductal breast cancer
Lymph node involvement is a major prognostic variable in breast cancer. Whether the molecular mechanisms that drive breast cancer cells to colonize lymph nodes are shared with their capacity to form distant metastases is yet to be established. In a transcriptomic survey aimed at identifying molecula...
ORGANISM(S): Homo sapiens 
2013-03-05 | E-GEOD-44408 | biostudies-arrayexpress
TranscriptomicsMOLECULAR CHARACTERIZATION OF LIVER ALLOGRAFTS FROM OPERATIONALLY TOLERANT TRANSPLANT RECIPIENTS
This SuperSeries is composed of the following subset Series: GSE26622: MOLECULAR CHARACTERIZATION OF LIVER ALLOGRAFTS FROM OPERATIONALLY TOLERANT TRANSPLANT RECIPIENTS (Affymetrix) GSE26625: MOLECULAR CHARACTERIZATION OF LIVER ALLOGRAFTS FROM OPERATIONALLY TOLERANT TRANSPLANT RECIPIENTS (Illumina) R...
ORGANISM(S): Homo sapiens 
2012-01-09 | E-GEOD-26627 | biostudies-arrayexpress
TranscriptomicsGenome-wide methylation profiling of multiple sporadic colorectal cancer
Background an Aim: Epigenetics are thought to play a major role in the carcinogenesis of patients that develop multiple colorectal cancers (CRC) in the non-hereditary setting. Previous studies have suggested concordant DNA hypermethylation between tumor pairs. However, only a few methylation markers...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-52573 | biostudies-arrayexpress
TranscriptomicsGene expression profiling and secretome analysis differentiate Adult-Derived Human Liver Stem/progenitor Cells and human hepatic stellate cells
Adult-derived human liver stem/progenitor cells (ADHLSC) are obtained after primary culture of the liver parenchymal fraction. The cells are of fibroblastic morphology and exhibit a hepato-mesenchymal phenotype. Hepatic stellate cells (HSC) derived from the liver non-parenchymal fraction present a c...
ORGANISM(S): Homo sapiens 
2015-05-11 | E-GEOD-49995 | biostudies-arrayexpress
TranscriptomicsA five-gene expression signature to predict progression in T1G3 bladder cancer
To analyze the gene expression profiles of progressive and non-progressive T1G3 bladder cancer (BCa) patients in order to develop a gene expression signature to predict tumour progression. Multicenter, retrospective study of formalin-fixed paraffin embedded (FFPE) tissue samples from 96 T1G3 BCa pat...
ORGANISM(S): Homo sapiens 
2016-07-29 | E-GEOD-57813 | biostudies-arrayexpress
TranscriptomicsExpression data from GNMT knockout mice in Hepatocytes and OKER cell lines
Hepatocellular carcinoma (HCC) is the first cause of death in cirrhotic patients. Liver cirrhosis at a high risk of HCC has abnormal S-Adenosylmethionine (SAMe) levels. Catabolism of SAMe is mainly mediated by Glycine N-methyltransferase (GNMT), Lack in GNMT expression leads to epigenetic regulation...
ORGANISM(S): Mus musculus 
2012-06-30 | E-GEOD-34838 | biostudies-arrayexpress
TranscriptomicsIntegrative analysis of microRNA and gene expression profiles identifies microRNAs as potential regulators in alcoholic hepatitis
Background & aims: The role of microRNAs (miRNAs) in Alcoholic Hepatitis (AH) and their potential as therapeutic targets in liver disease has not been explored yet. This study aims at profiling miRNA in AH and identifying dysregulated miRNAs involved in AH pathophysiology. Methods: miRNA expression...
ORGANISM(S): Homo sapiens 
2016-08-02 | E-GEOD-59492 | biostudies-arrayexpress
TranscriptomicsMolecular Characterization of Acute Cellular Rejection Occurring during Intentional Immunosuppression Withdrawal in Liver Transplantation
Acute cellular rejection occurs frequently during the first few weeks following liver transplantation. During this period its molecular phenotype is confounded by pro-inflammatory events elicited by surgery, ischemia-reperfusion injury and early post-transplant complications. To unambiguously define...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-70305 | biostudies-arrayexpress
TranscriptomicsTransportome profiling identifies profound alterations in Crohn’s disease partially restored by commensal bacteria
In the present study, the transcriptional analysis of CD biopsies reveals profound alterations in the ileum transportome profile. More than 60 SLC transporters showed different expression pattern compared with the healthy donors, being mostly decreased. Changes were confirmed in almost all the eight...
ORGANISM(S): Homo sapiens 
2016-03-29 | E-GEOD-68570 | biostudies-arrayexpress
TranscriptomicsTranscriptome Analysis from non-alcoholic steatohepatitis (NASH)
The mechanisms underlying the progression of non-alcoholic steatohepatitis (NASH) are not completely elucidated. In this study we have integrated gene expression profiling of liver biopsies of NASH patients with translational studies in a mouse model of steatohepatitis and with pharmacological inter...
ORGANISM(S): Homo sapiens 
2013-04-02 | E-GEOD-37031 | biostudies-arrayexpress
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