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ProteomicsStructure of an essential inner membrane protein-LPS complex identifies a novel anti-microbial peptide
Lipopolysaccharide (LPS) resides in the outer membrane (OM) of Gram-negative bacteria where it is responsible for barrier function and immune modulation. LPS is the target of polymyxins, last-resort antibiotics whose clinical use is threatened by increasing resistance. Steps in LPS biogenesis are ...
ORGANISM(S): Escherichia Coli K-12 (ncbitaxon:83333) 
2019-05-08 | MSV000083754 | MassIVE
TranscriptomicsThe Role of the E2F1 transcription factor in the innate immune response to systemic LPS [mRNA]
Our recent study of gene expression in mice treated with LPS systemically identified the E2F1 transcription factor as a novel regulator of innate immune response in lung, liver, and spleen tissue. Our follow up studies showed that RNAi-mediated inhibition or E2F1 gene deficiency lead to reduced infl...
ORGANISM(S): Mus musculus 
2012-06-30 | E-GEOD-33901 | biostudies-arrayexpress
ProteomicsProteomic and bioinformatic characterization of proteins secreted conventionally and unconventionally from human primary macrophages upon LPS transfection
The non-canonical caspase-4/5 inflammasome has been only very recently characterized. It is expressed by macrophages, the principal effector cells of the innate immunity system, and is activated by gram-negative bacteria, ER stress, and UV radiation. Activation of this inflammasome results in pyropt...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080769 | MassIVE
Unknown5-Lipoxygenase activating protein (FLAP) dependent leukotriene biosynthesis inhibition (MK591) attenuates Lipid A endotoxin-induced inflammation.
Not available
S-EPMC4099325 | biostudies-literature
ProteomicsSame same but different – The global response of Escherichia coli to five different LpxC inhibitors
A promising but yet clinically unexploited antibiotic target in difficult-to-treat Gram-negative bacteria is LpxC, the key enzyme in the biosynthesis of lipopolysaccharides (LPS), which are the major constituents of the outer membrane. To gain insights into the mode of action of five different LpxC ...
ORGANISM(S): Escherichia coli 
2024-06-16 | PXD043195 | Pride
Lipopolysaccharide Lps Antibiotics Phospholipid Outer membrane Ftsh 
UnknownCharacterization of an Acinetobacter baumannii lptD Deletion Strain: Permeability Defects and Response to Inhibition of Lipopolysaccharide and Fatty Acid Biosynthesis.
Not available
S-EPMC4751815 | biostudies-literature
ProteomicsLipopolysaccharide stimulates dynamic changes in B cell metabolism to promote cell proliferation - naive and LPS data
Following activation, naïve B cells exit quiescence and enter a proliferative phase before becoming mature antibody-producing or memory B cells. One method of activation is to use Lipopolysaccharide (LPS), a well-established B cell mitogen that can drive proliferation ex vivo. Using quantitative pro...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-18 | PXD057739 | Pride
UnknownDisrupting Gram-Negative Bacterial Outer Membrane Biosynthesis through Inhibition of the Lipopolysaccharide Transporter MsbA.
Not available
S-EPMC6201111 | biostudies-literature
TranscriptomicsTranscription profiling of human monocytic cells THP-1 stimulated with LPS (10ng/ml) in presence or absence of LL-37 (5 ug/ml), as well as with the peptide alone, for 4 hours
The objective of the study was to evaluate transcriptional response of endotoxin-stimulated human monocytic cells in presence or absence of host defense peptide LL-37 at low physiologically relevant concentrations. Human monocytic cells THP-1 were stimulated with LPS (10ng/ml) in presence or absenc...
ORGANISM(S): Homo sapiens 
2006-12-07 | E-FPMI-6 | biostudies-arrayexpress
UnknownEngineering a Gram-Negative Bactericidal Hydrogel: Cu<sub>x</sub>Te Nanozyme Functions as a Specific Killer by Hijacking LPS and Flagella Biosynthesis.
Not available
S-EPMC12932864 | biostudies-literature
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