Sort   by:  
 Page size 
TranscriptomicsTranscriptional profiling of small intestinal crypts from mice treated with Notch blocking antibodies or Notch blocking antibodies in combination with an Lrp6 blocking antibody.
The goal of this study was to identify genes that are differentially expressed during a 24 hour Notch blockade and whether a Wnt antagonist (anti-Lrp6) could block this effect. 3 condition experiment, Control untreated compared to N1N2 treated, and N1N2 treated compared to N1N2_Lrp6 treated. 5 biolo...
ORGANISM(S): Mus musculus 
2015-03-11 | E-GEOD-66751 | biostudies-arrayexpress
ProteomicsLRP6-BirA proximity labelling proteomics comparing wildtype and AP2 binding motif mutant (YYYF) LRP6 in FlpIn T-REx cells
Here we generated tetracycline inducible LRP6-BirA fusion lines in T-REx FlpIn cell lines for BioID proximity labelling proteomics experiments. We compare wt and mutant (YYYF>A mutant; mutates AP2 binding motifs to alanine) LRP6 binding partners following 12hrs Biotin labelling and Wnt3a treatment.
ORGANISM(S): Homo sapiens (Human) 
2025-04-30 | PXD054245 | Pride
Wnt Lrp6 Flpin hek293t Bioid 
ProteomicsWnt signalosome assembly is governed by conformational flexibility of Axin and AP2 clathrin adaptor
Wnt signal transduction relies on the direct inhibition of GSK3 by phosphorylated PPPSPxS motifs within the cytoplasmic tail of the LRP6 co-receptor. How GSK3 is recruited to LRP6 remains unclear. Here, we use nuclear magnetic resonance spectroscopy to identify the membrane-proximal PPPSPxS motif an...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2025-04-30 | PXD061649 | Pride
Gsk3 inhibition  lrp6 co-receptor  axin scaffold protein  ap2 cargo adaptor  clathrin-coated structures  wnt signalosome 
GenomicsTranscriptome analysis of LRP5- and LRP6-depleted HCC38 cells.
Transcriptome analysis of LRP5- and LRP6-depleted HCC38 cells.
PRJNA429432 | ENA
GenomicsSequencing facilitates quantitative analysis of transcriptomes in wild type and Lrp6-knockdown cells
Sequencing facilitates quantitative analysis of transcriptomes in wild type and Lrp6-knockdown cells
PRJNA399100 | ENA
TranscriptomicsTranscriptome analysis of LRP5- and LRP6-depleted HCC38 cells.
In order to characterize the differences between the co-receptors LRP5 and LRP6, we have analyzed the transcriptome of HCC38 cells - a triple negative breast cancer cell line - 24, 48 and 72 hours following the depletion of LRP5 or LRP6 using siRNAs.
ORGANISM(S): Homo sapiens 
2018-06-06 | GSE109004 | GEO
TranscriptomicsSequencing facilitates quantitative analysis of transcriptomes in wild type and Lrp6-knockdown cells
Purpose: The goals of this study are to determine the LRP6-mediated splicing regulation, and cellular transcriptomes from rat and human are analysised by deep sequencing. Methods: The mRNA profiles of WT and LRP6 KD were generated by deep sequencing, using Illumina HiSeq 4000. And the transcript iso...
ORGANISM(S): Rattus norvegicus Homo sapiens 
2018-08-20 | GSE102770 | GEO
GenomicsPharmaceutical reversal of Dkk1-induced LRP6 endocytosis prevents cancer cachexia and prolongs survival
Pharmaceutical reversal of Dkk1-induced LRP6 endocytosis prevents cancer cachexia and prolongs survival
PRJNA498701 | ENA
ProteomicsProximity Labeling using Lrp6-Apex2 Identifies Multivesicular Endosomes and TFG as Modulators of Canonical Wnt Signaling
Proximity Labeling using Lrp6-Apex2 Identifies Multivesicular Endosomes and TFG as Modulators of Canonical Wnt Signaling
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000084335 | MassIVE
GenomicsMapk7 regulates bone-fat balance by targeting Lrp6/β-catenin axis
Mapk7 regulates bone-fat balance by targeting Lrp6/β-catenin axis
PRJNA1075703 | ENA
Sort   by:  
 Page size