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TranscriptomicsExpression study of the Hodgkin’s lymphoma cell line L-1236 upon CRISPR Cas9-mediated knockout of lymphotoxin alpha (LTA) compared to control
Persistent activation of canonical and non-canonical NF-κB pathways is a hallmark of the malignant Hodgkin and Reed-Sternberg cells in classical Hodgkin lymphoma (cHL). We identified lymphotoxin alpha (LTA), which is secreted by the cHL cell line L-1236 in high concentrations. This cytokine contribu...
ORGANISM(S): Homo sapiens 
2019-01-24 | E-MTAB-6896 | biostudies-arrayexpress
TranscriptomicsOdontoblast-like cells and dental pulp fibroblasts stimulated with LTA, poly(I:C) and LPS.
Odontoblasts and fibroblasts are suspected to influence the innate immune response triggered in the dental pulp by micro-organisms that progressively invade the human tooth during the carious process. To determine whether they differ in their responses to oral pathogens, we performed a systematic co...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-9560 | biostudies-arrayexpress
ProteomicsDifferential impact of LPS and LTA stimulation on differentiated bone marrow and Yolk sac Hoxb8 macrophages
The impact of LPS and LTA stimulation on differentiated bone marrow and Yolk sac Hoxb8 macrophages in comparison to untreated control cells was studied by global protein profiling using a bottom-up approach.
ORGANISM(S): Mus musculus (Mouse) 
2022-02-04 | PXD026922 | Pride
Lps Lc-ms/ms Hoxb8 Bone marrow Yolk sac Lta Macrophages 
TranscriptomicsGene Expression Changes Associated With TLR2 Mediated Inhibition of Allergen Specific TH2 Response In Vitro
Investigation of the gene expression changes associated with TLR2 adjuvant (lipoteichoic acid; LTA) inhibition of allergic TH2 responses in peripheral blood mononuclear cell cultures (derived from house dust mite allergic individuals) stimulated with house dust mite extract. Pooled samples from 5 in...
ORGANISM(S): Homo sapiens 
2012-07-18 | E-GEOD-39476 | biostudies-arrayexpress
TranscriptomicsCirculating microRNA Signatures in Mice Exposed to Lipoteichoic acid
To profile the expression of circulating microRNAs (miRNAs) of mice in exposure to intraperitoneal lipoteichoic acid (LTA) injection and compare that with those with lipopolysaccharide (LPS) injection C57BL/6 mice received intraperitoneal injections of 100 M-NM-
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-41837 | biostudies-arrayexpress
GenomicsSingle cell RNA-seq of splenic Foxp3+ Treg from WT and Lta-/- mice
Single cell RNA-seq of splenic Foxp3+ Treg from WT and Lta-/- mice
PRJNA911209 | ENA
UnknownA Staphylococcus aureus ypfP mutant with strongly reduced lipoteichoic acid (LTA) content: LTA governs bacterial surface properties and autolysin activity.
Not available
S-EPMC2169524 | biostudies-literature
TranscriptomicsSingle cell RNA-seq of splenic Foxp3+ Treg from WT and Lta-/- mice
Single cell transcriptomic analyses reveal that Lta regulates the composition of splenic Foxp3+ Treg cells in C57BL/6J mice
ORGANISM(S): Mus musculus 
2024-12-31 | GSE220706 | GEO
TranscriptomicsExpression study of the Hodgkin’s lymphoma cell line L-1236 upon CRISPR Cas9-mediated knockout of lymphotoxin alpha (LTA) compared to control
Persistent NF-κB activation is a hallmark of the malignant Hodgkin/Reed-Sternberg (HRS) cells in classical Hodgkin lymphoma (cHL). Analysis of the cHL cell-secreted key factors for NF-κB activation by chromatography and subsequent mass spectrometry revealed lymphotoxin-α (LTA) as the causative facto...
ORGANISM(S): Homo sapiens 
2019-05-22 | GSE131559 | GEO
UnknownStaphylococcal LTA antagonizes the B cell-mitogenic potential of LPS.
Not available
S-EPMC5784022 | biostudies-literature
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