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TranscriptomicsRNA-seq of tumor organoids from patient-derived xenograft (PDX, LU-NB-2) of high-risk, MYCN-amplified neuroblastoma treated with prochlorperazine (PCZ), pitavastatin (PIT), the combination of both drugs, and untreated controls.
Neuroblastoma (NB) is a pediatric cancer characterized by significant heterogeneity and poor prognosis, especially in high-risk cases with MYCN amplification. Understanding the molecular response of neuroblastoma to different treatments can provide insights into potential therapeutic strategies. The...
2025-05-25 | E-MTAB-14846 | biostudies-arrayexpress
TranscriptomicsRNA-seq of subcutaneous patient-derived neuroblastoma xenografts (LU-NB-1) - Comparison of Prochlorperazine + Pitavastatin (PCZ+PIT) combination alone to one combined with standard-of-care COJEC protocol (PCZ+PIT+COJEC)
Neuroblastoma (NB) is a pediatric cancer characterized by significant heterogeneity and poor prognosis, specially in high-risk cases with MYCN amplification. Understanding the molecular response of neuroblastoma to different treatments can provide insights into potential therapeutic strategies. The ...
ORGANISM(S): Homo sapiens 
2025-07-30 | E-MTAB-14902 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling of Prostate Benign and Malignant Tissue
We profiled genome-wide gene expression of human prostate benign and malignant tissue to identify potential biomarkers and immunotherapy targets. We stratified malignant specimens according to their TMPRSS2:ERG gene fusion status. Radical prostatectomy tissue samples were obtained from the Hershey F...
ORGANISM(S): Homo sapiens 
2014-03-18 | E-GEOD-55945 | biostudies-arrayexpress
TranscriptomicsCharacterization of gene expression profile in HBV-related liver fibrosis patients
Hepatitis B virus (HBV) infection is a leading risk factor for liver fibrosis (LF) and hepatocellular carcinoma. Emerging evidence indicates that host genetic, virological and immunological factors will influence the fibrotic progress. Many previous studies have focused on specific pathways or genes...
ORGANISM(S): Homo sapiens 
2016-08-21 | E-GEOD-84044 | biostudies-arrayexpress
MetabolomicsChitin utilization by marine picocyanobacteria and the evolution of a planktonic lifestyle.
Marine picocyanobacteria Prochlorococcus and Synechococcus, the most abundant photosynthetic cells in the oceans, are generally thought to have a primarily single-celled and free-living lifestyle. However, while studying the ability of picocyanobacteria to supplement photosynthetic car...
2024-02-21 | MTBLS5229 | MetaboLights
UnknownPhase 3 Trial of 177Lu-Dotatate for Midgut Neuroendocrine Tumors.
Not available
S-EPMC5895095 | biostudies-literature
TranscriptomicsTranscription profiling of mouse knockouts for Etv4 and Etv5 - plusGDNF and minusGDNF comparison using U74Av2 and 430A arrays
GDNF signaling through the Ret receptor tyrosine kinase is critical for ureteric bud branching morphogenesis during kidney development yet few of the downstream genes are currently known. We find that the ETS transcription factors Etv4 and Etv5 are positively regulated by Ret signaling in ureteric b...
ORGANISM(S): Mus musculus 
2009-10-02 | E-GEOD-18267 | biostudies-arrayexpress
MetabolomicsMetabolomic Responses of Guard Cells and Mesophyll Cells to Bicarbonate
Anthropogenic CO2 presently at 400 ppm is expected to reach 550 ppm in 2050, an increment expected to affect plant growth and productivity. Paired stomatal guard cells (GCs) are the gate-way for water, CO2, and pathogen, while mesophyll cells (MCs) represent the bulk cell-type of green leaves mainly...
2017-03-31 | MTBLS309 | MetaboLights
TranscriptomicsIntegration of developmental and nutritional cues determines timing of female flower opening in cucumber
The timing of flower opening is essential for pollination and thus seed production. Despite flower opening has been a long lasting topic for plant biologists, the underling molecular mechansim remains elusive. Here we used a unique cucumber line ‘6457’ that spontaneously produces super ovary wit...
ORGANISM(S): Cucumis sativus 
2016-07-25 | E-GEOD-76358 | biostudies-arrayexpress
MetabolomicsLC-MS-Based Serum Metabolomics Reveals Distinct Metabolic Signatures in Patients with Cerebral Infarction

This study applied serum metabolomics to compare patients with cerebral infarction (n=10) and controls (n=10). A total of 3,160 metabolites were identified, with distinct class distributions between groups. Cerebral infarction patients showed elevated benzene derivatives, organic acids, and bile ...

2025-09-24 | MTBLS13031 | MetaboLights
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