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Transcriptomicsc-MET inhibitor inducing KSHV+ primary effusion lymphoma apoptosis
KSHV is a principal causative agent of primary effusion lymphoma (PEL). Despite this knowledge about the close relationship between HGF/c-MET network and solid tumors development, the role of HGF/c-MET in KSHV-related malignancies remains mostly unclear. We report that HGF/c-MET pathway is highly ac...
ORGANISM(S): Homo sapiens 
2016-01-05 | E-GEOD-70594 | biostudies-arrayexpress
TranscriptomicsGenome-wide replication analysis of a yeast eco1 mutant by deep sequencing.
Eco1 is the acetyltransferase that establishes sister-chromatid cohesion during DNA replication. Budding yeast with an eco1 mutation that genocopies Roberts syndrome displaysreduced ribosomal DNA (rDNA) transcription and a transcriptional signature of starvation. Weshow that deleting FOB1, a gene en...
ORGANISM(S): Saccharomyces cerevisiae 
2014-04-03 | E-GEOD-54742 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis comparing yeast Eco1 mutant W216G to mutants of FOB1 and RAD61
Eco1 is an acetyltransferase subunit of the cohesin complex and acts during DNA replication to establish cohesion between sister chromatids. However, cohesin has additional functions in gene expression, DNA damage repair, and higher-order organization of chromosomes. The eco1 mutant W216G disrupts a...
ORGANISM(S): Saccharomyces cerevisiae 
2014-04-03 | E-GEOD-54741 | biostudies-arrayexpress
TranscriptomicsThe cohesin acetyltransferase Eco1 coordinates rDNA replication and transcription
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Saccharomyces cerevisiae 
2014-04-03 | E-GEOD-54743 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene expression signatures for practical radiation biodosimetry
Genome-wide analysis of miRNA expression was performed in Activin A and Wnt3a-treated mouse ESCs during the different stages of DE differentiation to identify candidate miRNAs likely to be involved in Wnt3a and Activin A induced DE formation. Our analysis exhibited a distinct miRNA expression finger...
ORGANISM(S): Mus musculus 
2012-04-08 | E-GEOD-29093 | biostudies-arrayexpress
UnknownGenome-wide association study of paclitaxel and carboplatin disposition in women with epithelial ovarian cancer.
Not available
S-EPMC5784122 | biostudies-literature
UnknownGenomic insights into the origin, domestication and diversification of Brassica juncea.
Not available
S-EPMC8423626 | biostudies-literature
UnknownA reference library for Canadian invertebrates with 1.5 million barcodes, voucher specimens, and DNA samples.
Not available
S-EPMC6897906 | biostudies-literature
UnknownInnate lymphoid cells and COVID-19 severity in SARS-CoV-2 infection.
Not available
S-EPMC9038195 | biostudies-literature
TranscriptomicsMutations in cohesin-associated genes impair protein translation
The cohesin protein complex is well known for playing a role in chromosome segregation. However, it has additional less understood roles in transcription, DNA repair, and chromosome condensation. Mutants in two yeast orthologues (Eco1 and Scc2) of human cohesinopathy disease alleles were examined by...
ORGANISM(S): Saccharomyces cerevisiae 
2011-04-01 | E-GEOD-27235 | biostudies-arrayexpress
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