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TranscriptomicsRole of Tet3 and DNA replication in zygotic demethylation of both paternal and maternal genomes [RNA-seq]
With the exception of imprinted genes and certain repeats, DNA methylation is globally erased during pre-implantation development. Recent studies have suggested that Tet3-mediated oxidation of 5-methylcytosine (5mC) and DNA replication-dependent dilution both contribute to global paternal DNA demeth...
ORGANISM(S): Mus musculus 
2014-10-21 | E-GEOD-61329 | biostudies-arrayexpress
GenomicsRole of Tet3 and DNA replication in zygotic demethylation of both paternal and maternal genomes [RRBS]
With the exception of imprinted genes and certain repeats, DNA methylation is globally erased during pre-implantation development. Recent studies have suggested that Tet3-mediated oxidation of 5-methylcytosine (5mC) and DNA replication-dependent dilution both contribute to global paternal DNA demeth...
ORGANISM(S): Mus musculus 
2014-10-21 | E-GEOD-61330 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in ref6-1
We demonstrate that REF6/JMJ12 (RELATIVE OF EARLY FLOWERING 6/Jumonji domain-containing protein 12) is an H3K27me3 and H3K27me2 demethylase. Plants overexpressing REF6/JMJ12 resemble mutants defective in H3K27me3-mediated gene silencing. Genetic interaction tests indicate that REF6/JMJ12 acts downst...
ORGANISM(S): Arabidopsis thaliana 
2011-05-25 | E-GEOD-25444 | biostudies-arrayexpress
GenomicsGenome-wide comparison of H3K27me3 difference between ref6-1 and wild type Col
We demonstrate that REF6/JMJ12 (RELATIVE OF EARLY FLOWERING 6/Jumonji domain-containing protein 12) could demethylate H3K27me3. Loss of REF6/JMJ12 leads to ectopic and increased H3K27me3 of a large spectrum of genes involved in development and responses to stimuli. Examination of differences in H3K2...
ORGANISM(S): Arabidopsis thaliana 
2011-05-25 | E-GEOD-25446 | biostudies-arrayexpress
TranscriptomicsTet proteins in DNA demethylation and cell fate restriction
DNA methylation at 5-position of cytosine (5mC) is one of the best studied epigenetic modifications that plays important roles in diverse biological processes. Iterative oxidation of 5mC by the Ten-eleven translocation (Tet) family of proteins generates 5-hydroxymethylcytosine (5hmC), 5-formylcytosi...
ORGANISM(S): Mus musculus 
2014-09-22 | E-GEOD-56986 | biostudies-arrayexpress
TranscriptomicsProtein arginine methyltransferase AtPRMT5 is involved in pre-mRNA splicing in Arabidopsis thaliana
In this study, we analyzed the Arabidopsis homologue of PRMT5, AtPRMT5M-bM-^@M-^Ys function in RNA processing. RNA-seq analyses revealed that AtPRMT5 is involved in a subset of pre-mRNA splicing. Several RNA processing factors involved in regulating flowering time were validated that the correspondi...
ORGANISM(S): Arabidopsis thaliana 
2010-10-07 | E-GEOD-21323 | biostudies-arrayexpress
GenomicsREF6 recognizes specific DNA sequence to regulate H3K27me3 demethylation and organ boundary formation
RELATIVE OF EARLY FLOWERING 6 (REF6, also known as JMJ12) counteracts Polycomb mediated gene silencing through demethylating histone H3 lysine 27 trimethylation (H3K27me3) in Arabidopsis. Genome-wide analysis has demonstrated that REF6 dependent H3K37me3 demethylation occurs on hundreds of genes. Ho...
ORGANISM(S): Arabidopsis thaliana 
2016-03-22 | E-GEOD-65329 | biostudies-arrayexpress
ProteomicsMARTRE family proteins negatively regulate CCR4-NOT activity to protect poly(A) tail length and promote translation of maternal mRNA
Proteomic dataset generated in the project for study the molecular function of MARTRE proteins
ORGANISM(S): Mus Musculus 
2024-11-25 | PXD051636 |
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