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MetabolomicsA polyamine-centric blood-based metabolite panel predictive of poor response to CAR T-cell therapy in large B cell lymphoma

Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy for relapsed or refractory (r/r) large B-cell lymphoma (LBCL) results in durable response in only a subset of patients. MYC overexpression in LBCL tumors is associated with poor response to treatment. We tested whether a MYC-driven polyamin...

2022-10-31 | MTBLS5381 | MetaboLights
MetabolomicsContributions of the Microbiome-Derived Metabolome for Risk Assessment and Prognostication of Pancreatic Cancer

BACKGROUND Increasing evidence implicates microbiome involvement in the development and progression of pancreatic ductal adenocarcinoma (PDAC). Studies suggest that reflux of gut or oral microbiota can lead to colonization in the pancreas, resulting in dysbiosis that culminates ...

2023-08-09 | MTBLS7260 | MetaboLights
ProteomicsThe Omicron variant-associated cardiac injury mechanism in rhesus macaques is revealed by a proteome and phosphoproteomic map ( phosphoproteomic and proteome data)
Here, we identified proteins and phosphosites that were differentially regulated during infection with the Omicron variant using cardiac proteomics and phosphoproteomics. Our results demonstrate alterations in the global landscape of the cardiac proteome and phosphoproteome following infection with ...
ORGANISM(S): Macaca Mulatta 
2024-04-21 | PXD051632 |
ProteomicsProteomic and phosphoproteomic profiling of COVID-19-associated lung injury: a report based on rhesus macaques
Lung is the major organ affected by SARS-CoV-2. To explore the molecular mechanism in the lung after SARS-CoV-2 infection, we performed LC-MS based proteome and phosphoproteome analysis using lung tissue samples separated from rhesus macaques.
ORGANISM(S): Macaca Mulatta 
2021-07-08 | PXD027180 |
ProteomicsProteomic and phosphoproteomic profiling of COVID-19-associated liver injury: a report based on rhesus macaques
Almost 50% of COVID-19 patients have symptoms of liver injury. To explore the molecular mechanism in the livers after SARS-CoV-2 infection, we performed LC-MS based proteome and phosphoproteme analysis using liver tissue samples separated from rhesus macaques.
ORGANISM(S): Macaca Mulatta 
2021-07-08 | PXD027179 |
ProteomicsGlobal profiling of protein lactylation in Human hippocampi
Lysine lactylation (Kla) is a novel posttranslational modification, playing important roles in numerous biological processes, including transcription, metabolism, tumorigenesis and nervous system diseases. Using liquid chromatography-tandem mass spectrometry (LC-MS/MS), researchers have identified l...
ORGANISM(S): Homo Sapiens 
2024-03-08 | PXD050470 |
MetabolomicsLipopolysaccharides from Ralstonia solanacearum induce a broad metabolomic response in Solanum lycopersicum

Ralstonia solanacearum, one of the most destructive crop pathogens worldwide, causes bacterial wilt disease in a wide range of host plants. The major component of the outer membrane of Gram-negative bacteria, lipopolysaccharides (LPS), has been shown to function as elicitors of plant defense lead...

2023-08-08 | MTBLS7324 | MetaboLights
UnknownElliptic anisotropy measurement of the f<sub>0</sub>(980) hadron in proton-lead collisions and evidence for its quark-antiquark composition.
Not available
S-EPMC12391314 | biostudies-literature
UnknownRivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial.
Not available
S-EPMC6662613 | biostudies-literature
UnknownSARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
Not available
S-EPMC7995808 | biostudies-literature
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