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MetabolomicsShort-Term Clinical Response and Changes in the Fecal Microbiota and Metabolite Levels in Patients with Crohn's Disease After Stem Cell Infusions
Recent studies have shown a close relationship between the gut microbiota and Crohn's disease (CD). This study aimed to determine whether mesenchymal stem cell (MSC) treatment alters the gut microbiota and fecal metabolite pathways and to establish the relationship between the gut microbiota and fec...
2025-07-03 | MTBLS6288 | MetaboLights
UnknownApigenin mitigates intestinal barrier dysfunction in sepsis by modulating the AKT signaling pathway.
Not available
S-EPMC12398084 | biostudies-literature
ProteomicsPhosphoproteomic and proteomic profiling in post-infarction chronic heart failure
We conducted a global quantitative phosphoproteomic and proteomic analysis of left ventricular (LV) tissues from post-infarction chronic heart failure rats. Phosphoproteomic and proteomic analysis can provide insights regarding molecular mechanisms underlying post-infarction chronic heart failure an...
ORGANISM(S): Rattus Norvegicus 
PXD042843 |
ProteomicsSpatiotemporally-resolved mapping of extracellular proteomes via in vivo-compatible TyroID
Extracellular proteins play pivotal roles in both intracellular signaling and intercellular communications in health and disease. While recent advancements in proximity labeling (PL) methods, such as peroxidase- and photocatalyst-based approaches, have facilitated the resolution of extracellular pro...
ORGANISM(S): Homo Sapiens Mus Musculus Bos Taurus 
2024-11-21 | PXD054796 |
MetabolomicsExtracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness
The accumulation of acidic metabolic waste products within the tumor microenvironment profoundly inhibits effector functions of tumor-infiltrating lymphocytes (TILs). However, it is unclear whether extracellular-acidosis impacts T cell metabolic fitness and differentiation status. Here, we surprisin...
2023-01-17 | MTBLS6661 | MetaboLights
ProteomicsMulti-organ Proteomic and Phosphoproteomic Profiles of Mpox Virus Infection in SIVmac239-infected Rhesus Macaques
Macaque study was conducted in an ABSL-3 facility, adhering to protocols approved by the Institutional Animal Care and Use Committee (IACUC) under the guidelines of the Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (Approval Number XJ23004). All animals were single-hous...
ORGANISM(S): Macaca Mulatta 
PXD056753 |
ProteomicsCyclic immonium ion of lactyllysine reveals widespread lactylation in the human proteome
Here we employed a non-enzymatic chemical labeling approach to introduce lactylation on lysine residues of model peptides and proteins. Tandem MS acquisition of lactylated peptide carriers on different MS platforms unequivocally led us to note an intense peak corresponding to the “cyclic” immonium ...
ORGANISM(S): Homo Sapiens 
PXD028488 |
ProteomicsTargeting ubiquitin-independent proteasome with small molecule increases susceptibility in pan-KRAS mutant cancers
Despite advances in the development of direct KRAS inhibitors, KRAS-mutant cancers continue to exhibit resistance to the currently available therapies. Here, we identified REGγ as a mutant KRAS-associated factor that enhances REGγ transcription through the KRAS intermediate NRF2, suggesting that the...
ORGANISM(S): Homo Sapiens 
2025-01-01 | PXD059364 |
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