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TranscriptomicsALKBH5 is a New Mammalian RNA Demethylase
N6-methyladenosine (m6A) is the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Here we report ALKBH5 as a new mammalian demethylase that oxidatively removes the m6A modification in mRNA in vitro and inside cells. This demethylation activity of ALKBH5 significantly...
ORGANISM(S): Mus musculus 
2013-02-15 | E-GEOD-40132 | biostudies-arrayexpress
Transcriptomicsm6A-dependent regulation of messenger RNA stability
N6-methyladenosine (m6A) is the most prevalent internal modification present in the mRNA of all higher eukaryotes. Here we present that m6A is selectively recognized by human YTH domain family (YTHDF2) protein to regulate mRNA degradation. By using crosslinking and immunoprecipitation, we have ident...
ORGANISM(S): Homo sapiens 
2013-11-29 | E-GEOD-49339 | biostudies-arrayexpress
UnknownEfficacy and safety of Suhuang Zhike capsule (苏黄止咳胶囊) for cough variant asthma: a multicenter, single-arm, open-label phase IV real-world clinical trial
Not available
S-EPMC12340594 | biostudies-literature
TranscriptomicsProtein arginine methyltransferase AtPRMT5 is involved in pre-mRNA splicing in Arabidopsis thaliana
In this study, we analyzed the Arabidopsis homologue of PRMT5, AtPRMT5M-bM-^@M-^Ys function in RNA processing. RNA-seq analyses revealed that AtPRMT5 is involved in a subset of pre-mRNA splicing. Several RNA processing factors involved in regulating flowering time were validated that the correspondi...
ORGANISM(S): Arabidopsis thaliana 
2010-10-07 | E-GEOD-21323 | biostudies-arrayexpress
TranscriptomicsStructural basis of YTH domain as m6A reader
The N6-methyladenosine (m6A) is the most abundant internal modification in almost all eukaryotic messenger RNAs, and is dynamically regulated. Therefore, identification of m6A readers is especially important in determining the cellular function of m6A. YTHDF2 has recently been characterized as the f...
ORGANISM(S): Homo sapiens 
2014-09-18 | E-GEOD-58352 | biostudies-arrayexpress
TranscriptomicsNCI-H1299 cell line transfected with human DENND2D and vector
Gene expression for NCI-H1299 cell line transfected with human DENND2D and vector (pcDNA3.1/V5-His TOPO TA vector) respectively. The microarray experiment was designed to perform four replicates for each H1299-DENND2D and H1299-vector sample. cRNA used in replication 1 and 2 was from the same label...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-16890 | biostudies-arrayexpress
TranscriptomicsA transcriptomic analysis of super-hybrid rice LYP9 and its parental lines
Using a whole-genome oligonucleotide microarray designed based on known and predicted indica rice genes, we investigated transcriptome profiles in developing leaves and panicles of super hybrid rice LYP9 and its parental cultivar 93-11 and PA64s. We detected 22,266 expressed genes out of 36,926 tota...
ORGANISM(S): Oryza sativa 
2009-04-22 | E-GEOD-14729 | biostudies-arrayexpress
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