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MetabolomicsA general non-self response as part of plant immunity
Plants, like other multicellular lifeforms, are colonized by microorganisms. How plants respond to their microbiota is currently not well understood. We used a phylogenetically diverse set of 39 endogenous bacterial strains from Arabidopsis thaliana leaves to assess host transcriptional and metaboli...
2021-09-13 | MTBLS2522 | MetaboLights
ProteomicsMachine learning for grading and prognosis of esophageal dysplasia using mass spectrometry and histological imaging
Background: Barrett’s esophagus (BE) is a precursor lesion of esophageal adenocarcinoma and may progress from non-dysplastic through low-grade dysplasia (LGD) to high-grade dysplasia (HGD) and cancer. Grading BE is of crucial prognostic value and is currently based on the subjective evaluation of bi...
ORGANISM(S): Homo sapiens (Human) 
2021-11-15 | PXD028949 | Pride
Deep learning Mass spectrometry imaging H&e staining Barrett’s esophagus Machine learning 
ProteomicsProteomic analysis Carcinoma associated fibroblasts (CAFs) following genetic manipulation of NID2 expression
Proteomic anlaysis was performed on CAF GFP-1 KRAB, CAF B500 NID2 KRAB and CAF C500 NID2 KRAB cell lines
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD050045 | Pride
Carcinoma associated fibroblasts Nid2 
ProteomicsTemporally-resolved proteomic profiling of mouse pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is characterized by progressive matrix deposition and fibrosis, which can enhance tumor progression and spread. Here, we undertook an unbiased temporal assessment of the matrix proteome (matrisome) of the highly-metastatic KPC and poorly-metastatic KPflC mouse...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-10 | PXD045830 | Pride
Cancer Pancreas Extracellular matrix 
TranscriptomicsTranscription profiling of mouse multipotent adult progenitor cells
We compare the transcriptome of embryonic stem cells (ESCs), adult stem cells with apparent greater differentiation potential such as multipotent adult progenitor cells (MAPCs), mesenchymal stem cells (MSCs) and neurospheres (NS). Mouse and rat MAPCs were used in this study and two different array p...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6933 | biostudies-arrayexpress
TranscriptomicsHematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cells
We used comparative transcriptome analysis to determine the relationship between rodent Multipotent Adult Progenitor Cells (MAPCs) and pluripotent embryonic stem cells (ESCs), or lineage restricted mesenchymal stem cells (MSCs) and neurospheres (NS). This comparison revealed a unique gene expression...
ORGANISM(S): Mus musculus 
2010-06-11 | E-GEOD-5947 | biostudies-arrayexpress
UnknownAssociation between left ventricular ejection fraction, mortality and use of mechanical circulatory support in patients with non-ischaemic cardiogenic shock.
Not available
S-EPMC10954940 | biostudies-literature
GenomicsPaternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (meDIP)
Epigenetic information can be inherited through the mammalian germline, and represents a plausible transgenerational carrier of environmental information. To test whether transgenerational inheritance of environmental information occurs in mammals, we carried out an expression profiling screen for g...
ORGANISM(S): Mus musculus 
2011-01-14 | E-GEOD-25898 | biostudies-arrayexpress
TranscriptomicsPaternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (small RNA)
Characterized the small (19-35 bp) RNA population from control and low protein offspring livers by high throughput sequencing. Eight sequencing lanes, one for each animal, with an average of 3.7 million mappable reads per lane. A number of miRNAs changed expression in the offspring from low protein ...
ORGANISM(S): Mus musculus 
2011-01-14 | E-GEOD-25897 | biostudies-arrayexpress
TranscriptomicsPaternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals
This SuperSeries is composed of the following subset Series: GSE25895: Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (dye swap) GSE25896: Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammal...
ORGANISM(S): Mus musculus 
2011-01-14 | E-GEOD-25899 | biostudies-arrayexpress
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