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ProteomicsEffects of age and sex on protein abundance in the mouse heart
We compared protein abundance in the left and right ventricles of male and female C57BL6/J mice at 4 months and 20 months old. Frozen tissues were weighed, thawed, and cut into small pieces (2-3 mm3) on weigh boats on ice. Tissue pieces were transferred to 2.0 mL eppendorf tubes. Cold RIPA (Thermo #...
ORGANISM(S): Mus Musculus (mouse) 
2022-11-08 | PXD033719 | JPOST Repository
ProteomicsSimultaneous proteome localization and turnover analysis of cardiomyocytes under proteasome inhibition
To examine the protein spatial and temporal changes upon carfilzomib-mediated proteasome inhibition in cardiac cells, we produced human iPSC-derived cardiomyocytes using a standard small molecule based protocol. Cardiomyocyte identity was confirmed by morphology, observation of contraction, and the ...
ORGANISM(S): Homo Sapiens (human) 
2023-04-28 | PXD041386 | JPOST Repository
ProteomicsSimultaneous proteome localization and turnover analysis reveals spatiotemporal coordinations of unfolded protein response
The functionality of proteins is dependent on their spatial and temporal distributions, neither of which is directly measured by static protein abundance. Here we report a mass spectrometry-based proteomics workflow and data analysis pipeline, named Simultaneous Proteome Localization and Turnover (...
ORGANISM(S): Homo Sapiens (human) 
2022-12-31 | PXD038054 | JPOST Repository
UnknownIdentification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.
Not available
S-EPMC3017602 | biostudies-literature
ProteomicsAmino acid and heavy water labelling to obtain protein turnover rates in intact adult animals
Both labelling studies were conducted with C57/BL6J adult male mice, derived from the same supplier and maintained under identical conditions. Eleven adult male C57BL/6JOlaHsd mice (Harlan UK Ltd., Shardlow, UK) of over 12 months of age at the start of the experiment were housed individually in 48 x...
ORGANISM(S): Mus Musculus (mouse) 
2021-12-13 | PXD029639 | JPOST Repository
UnknownGermline variants and advanced colorectal adenomas: adenoma prevention with celecoxib trial genome-wide association study.
Not available
S-EPMC4037290 | biostudies-literature
UnknownComparison of cardiovascular risk factors between children and adolescents with classes III and IV obesity: findings from the APV cohort.
Not available
S-EPMC8081660 | biostudies-literature
ProteomicsMass spectrometry-based draft of the mouse proteome
Quantitative draft map of the proteomes of 41 healthy tissues of the animal model Mus musculus and a panel of 66 murine pancreatic ductal adenocarcinoma cell lines and. Our in-depth analysis provides evidence for proteins encoded by >16,000 genes (~76% of the total annotated protein-coding genes), w...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-07-09 | MSV000089856 | MassIVE
UnknownDevelopment and validation of the NEOS2 score for prediction of long-term outcomes and improvement after first-line immunotherapy in patients with anti-NMDAR encephalitis: an international cohort study.
Not available
S-EPMC12757447 | biostudies-literature
UnknownEffects of snake fungal disease (ophidiomycosis) on the skin microbiome across two major experimental scales.
Not available
S-EPMC11959348 | biostudies-literature
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