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TranscriptomicsTranscriptional profiling of zebrafish embryos after 96 h exposure to two subsequent concentrations of 4-methyl-3-deoxy-1,9,12-trihydroxyestra-1,3,5(10)7-tetraene-6,17-dione (MDTETD) and 12β-trihydroxy-androsta-4,6-diene-3,17-dione (THADD)
The aim of this mRNA expression profiling experiment was to screen for ecotoxicogenomic fingerprints in zebrafish (Danio rerio) embryos as aquatic vertebrate non-target model exposed to sublethal concentrations of 4-methyl-3-deoxy-1,9,12-trihydroxyestra-1,3,5(10)7-tetraene-6,17-dione (MDTETD) and 12...
ORGANISM(S): Danio rerio 
2021-10-11 | E-MTAB-10922 | biostudies-arrayexpress
UnknownChanges in the serotype distribution of Streptococcus pneumoniae causing otitis media after PCV13 introduction in Spain.
Not available
S-EPMC6298674 | biostudies-literature
UnknownSlowing Heart Rate Protects Against Pathological Cardiac Hypertrophy.
Not available
S-EPMC9761894 | biostudies-literature
UnknownNanoscale resolved mapping of the dipole emission of hBN color centers with a scattering-type scanning near-field optical microscope.
Not available
S-EPMC11831392 | biostudies-literature
UnknownOpposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism.
Not available
S-EPMC6554672 | biostudies-literature
ProteomicsE-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/A9 release from neutrophils via transient gasdermin D pore formation
S100A8/A9 is a proinflammatory mediator released by myeloid cells during many acute and chronic inflammatory disorders. However, the precise mechanism of its release from the cytosolic compartment of neutrophils is still elusive. We report here that E-selectin-induced rapid S100A8/A9 release during ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-25 | PXD041652 | Pride
Neutrophile Inflammation Gasdermin d Transient pore formation 
UnknownMicrobiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition.
Not available
S-EPMC8043748 | biostudies-literature
ProteomicsDistinct and stage-specific contributions of TET1 and TET2 to stepwise cytosine oxidation in the transition from naive to primed pluripotency
Cytosine DNA bases can be methylated by DNA methyltransferases and subsequently oxidized by TET proteins. The resulting 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) are considered demethylation intermediates as well as stable epigenetic marks. To dissect the ...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-24 | PXD019514 | Pride
Epigenetics Epiblast-like cells Mouse embryonic stem cells Dna methylation 
ProteomicsTET1 interactome in mESCs (via ChIP-MS)
Precise regulation of DNA methylation in mammals is critical for genome stability and epigenetic regulation. The discovery of the ten-eleven translocation (TET) proteins catalyzing the oxidation from 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcyto...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-31 | PXD028850 | Pride
Epigenetics Tet1 Mouse embryonic stem cells Dna methylation 
UnknownCasein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer's disease.
Not available
S-EPMC8339060 | biostudies-literature
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