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TranscriptomicsNFAT-dependent IL-2 and IL-23 produced by DC are key regulators of pathogenic (TH17-mediated lung inflammation)
Calcineurin/NFAT/IL-2 signaling pathway is activated in dendritic cells (DC) upon encounter of β glucan, the main component of the fungal cell wall, raising the question about the role of NFAT-regulated genes in DC biology in vivo. To directly assess the function of IL-2 secreted by DC, we analyzed...
ORGANISM(S): Mus musculus 
2015-12-21 | E-GEOD-58590 | biostudies-arrayexpress
TranscriptomicsC-Myb+ erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages
Although classified as hematopoietic cells, tissue-resident macrophages are selfrenewing and maintained independently of adult hematopoiesis. While most macrophages originate from embryonic precursors that seed tissues prior to birth, their exact origin is unknown. Using an in utero macrophage deple...
ORGANISM(S): Mus musculus 
2015-04-23 | E-GEOD-66970 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of the genetic regulation of gene expression in human neutrophils
Here we report an expression dataset of isolated neutrophils from 114 healthy individuals of Chinese ethnicity collected in Singapore. A total of 114 individuals with no case control stratification.
ORGANISM(S): Homo sapiens 
2015-08-10 | E-GEOD-70044 | biostudies-arrayexpress
ProteomicsMicroglia and brain organoids
iPSC-derived microglia export cholesterol to neuronal cells in human brain organoids and promote their maturation
ORGANISM(S): Homo Sapiens (human) 
2023-05-19 | PXD042344 | JPOST Repository
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