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ProteomicsSecretome analysis of Pancreatic Cancer Spheroid with myeloid cell infiltration
Pancreatic ductal adenocarcinoma (PDAC) is one of the most hypoxic, lethal, and treatment resistant cancers. Due to its desmoplastic and hypoxic nature along with the abundance of myeloid cell infiltration and scare T cell infiltration, PDAC is considered a cold tumor. Using MiaPaCA-2 as a PDAC sphe...
ORGANISM(S): Homo sapiens (Human) 
2023-12-15 | PXD044177 | Pride
Human Spheroid Pancreatic cancer Pdac Miapaca2 Lc-ms/ms 
ProteomicsHigh throughput generation of a resource of the human secretome in mammalian cells
The proteins secreted by human tissues (the secretome) are important for the basic understanding of human biology, but also for identification of potential targets for future diagnosis and therapy. Here, we present an annotation of all predicted secreted proteins (n=2,623) with information about the...
ORGANISM(S): Homo Sapiens 
2021-03-15 | PXD012054 | panorama
TranscriptomicsIL-15 activates mTOR and primes stress-activated gene-expression leading to prolonged anti-tumor capacity of NK cells
Treatment of hematological malignancies by adoptive transfer of activated natural killer (NK) cells is limited by poor post-infusion persistence. We compared the ability of interleukin-2 (IL-2) and IL-15 to sustain human NK cell functions following cytokine withdrawal to model post-infusion performa...
ORGANISM(S): Homo sapiens 
2016-08-24 | E-GEOD-77808 | biostudies-arrayexpress
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