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2',3,5-Trimethoxychalcone (MC-23) triggers apoptosis independently of p53 in MiaPaCa2 cells. To understand the mechanism of action of MC-23, we analysed the gene expression profiles in MiaPaCa2 cells treated with 10 M-NM-
ORGANISM(S): Homo sapiens 
Sensitivity of MiaPaCa2 cells to E2F inhibitor Ly101-4B.
We and others have shown that AGR2 is frequently upregulated during the development of pancreatic cancer. We used microarray to look at the target genes regulated by AGR2 in pancreatic cancer cell lines FA6 and MiaPaCa2. Keywords: gene knock-down, overexpression We transiently down-regulated AGR2 e...
ORGANISM(S): Homo sapiens 
MiaPaCa2 cells where screened with a set of original compounds with anticancer activity available at our laboratory. From these compounds we identified the nucleoside analogue ly101-4B as a strong inhibitor of the E2F activity. We confirmed its activity by studying its effect on MiaPaCa2's cell viab...
ORGANISM(S): Homo sapiens 
2019-02-28 | GSE109853 | GEO
Next generation sequencing facilities quantitative analysis of ASAP2 knockout or wild-type Panc1 and MiaPaCa2 cells
2',3,5-Trimethoxychalcone (MC-23) triggers apoptosis independently of p53 in MiaPaCa2 cells. To understand the mechanism of action of MC-23, we analysed the gene expression profiles in MiaPaCa2 cells treated with 10 μM MC-23 for 6, 12, or 24 h using the Agilent human 44K oligonucleotide V2 microarra...
ORGANISM(S): Homo sapiens 
2014-01-21 | GSE54225 | GEO
We and others have shown that AGR2 is frequently upregulated during the development of pancreatic cancer. We used microarray to look at the target genes regulated by AGR2 in pancreatic cancer cell lines FA6 and MiaPaCa2. Keywords: gene knock-down, overexpression
ORGANISM(S): Homo sapiens 
2013-07-28 | GSE12513 | GEO
To assess potential gene expression changes by ASAP2 individual knockout in Panc1 and MiaPaCa2 cells, we performed a transcriptomic analysis using high throughput RNA sequencing (RNA-seq).
ORGANISM(S): Homo sapiens 
2020-04-27 | GSE149359 | GEO
S100PBP is significantly down-regulated in pancreatic cancer compared to normal samples. The functional roles of S100PBP are unknown, and therefore, profiling cells after silencing of this gene may lead to further understanding of its functional mechanisms. We have performed microarray gene expressi...
ORGANISM(S): Homo sapiens 
tumor-stroma crosstalk drives pancreatic carcinogenesis we used time-resolved genome-wide transcriptional profiling to analyse changes caused by co-exposure of pancreatic tumor and stellate cells pancreatic tumor cell line MiaPaca2 was treated with a supernatant of pancreatic stelalte cells, primed ...
ORGANISM(S): Homo sapiens 
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