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TranscriptomicsMouse lung CD103+ and CD11b-high dendritic cell (DC) subsets
Mouse lung CD11c+ dendritic cells are composed of 2 major DC subsets, the CD103+CD11b-low/intermediate DC (CD103+ DC) and the CD11b-highCD103- DC (CD11b-high DC). These 2 subsets are functionally distinct. Comparison of their functions showed CD103+ DC Microarray analysis was performed to compare ...
ORGANISM(S): Mus musculus 
2010-03-24 | E-GEOD-17322 | biostudies-arrayexpress
TranscriptomicsGenome-wide microRNA expression profiling identifies miR-9-3 and miR-193a as targets for DNA methylation in non-small cell lung cancers
Purpose: The major aim of this study was to investigate the role of DNA methylation (referred to as methylation) on microRNA (miRNA) silencing in non-small cell lung cancers (NSCLC). Experimental Design: We performed microarray expression analyses of 856 miRNAs in NSCLC A549 cells before and after t...
ORGANISM(S): Homo sapiens 
2012-03-13 | E-GEOD-31579 | biostudies-arrayexpress
TranscriptomicsAnalyses of lung early responses to RSV in the neonatal environment reveal key roles for DC and type I IFN in controlling immunopathologic imprinting.
The gene expression profile of neonatal versus adult lung, 2 days after an RSV or mock infection was analyzed using whole mouse genome agilent microarrays. Total lung RNA were extracted, labeled with Cy3 and hybridized on Agilent G4122F slides. We used 4 biological replicates per condition.
ORGANISM(S): Mus musculus 
2015-12-21 | E-GEOD-42759 | biostudies-arrayexpress
TranscriptomicsNFAT-dependent IL-2 and IL-23 produced by DC are key regulators of pathogenic (TH17-mediated lung inflammation)
Calcineurin/NFAT/IL-2 signaling pathway is activated in dendritic cells (DC) upon encounter of β glucan, the main component of the fungal cell wall, raising the question about the role of NFAT-regulated genes in DC biology in vivo. To directly assess the function of IL-2 secreted by DC, we analyzed...
ORGANISM(S): Mus musculus 
2015-12-21 | E-GEOD-58590 | biostudies-arrayexpress
ProteomicsAnalysis of Immune Checkpoint Drug Targets and Tumor Proteotypes in Non-Small Cell Lung Cancer
New therapeutics targeting immune checkpoint proteins have significantly advanced treatment of non-small cell lung cancer (NSCLC), but protein level quantitation of drug targets presents a critical problem. We used multiplexed, targeted mass spectrometry (MS) to quantify the immunotherapy target pr...
ORGANISM(S): Homo Sapiens 
2020-06-22 | PXD019061 | panorama
ProteomicsProteomic analysis of nonsmall cell lung cancer
These data correspond to PMID: 22761400, "In-depth proteomic analysis of nonsmall cell lung cancer to discover molecular targets and candidate biomarkers." (Mol Cell Proteomics. 2012 Oct;11(10):916-32. Epub 2012 Jul 3.)
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2013-11-18 | MSV000078491 | MassIVE
TranscriptomicsGene expression of distinct lung dendritic cell subsets
Pulmonary dendritic cells are heterogenous cells comprise four distinct subsets including two conventional dendritic cell subsets, CD103+ and CD11bhiCD14lo cells, and two monocyte-derived dendritic cell subsets. Their functions in terms of migration and T cell activation are distinct, but genes regu...
ORGANISM(S): Mus musculus 
2015-04-02 | E-GEOD-64896 | biostudies-arrayexpress
TranscriptomicsNormal Lung + Lung adenocarcinoma microarray
Gene transcription in a set of 49 human primary lung adenocarcinomas and 9 normal lung tissue samples was examined using Affymetrix GeneChip technology. We aimed to investigate differential gene expression between the two tissue types. A total of 3,442 genes, called the set MAD, were found to be eit...
ORGANISM(S): Homo sapiens 
2005-12-31 | E-MEXP-231 | biostudies-arrayexpress
TranscriptomicsAnalysis of normal lung cells treated with 5-aza-dC to induce DNA demethylation
Analysis of 2 cultured normal lung cell lines, Normal Human Bronchial Epithelial (NHBE) and Human Small Airway Epithelial (SAEC) cells (Lonza, Walkersville, MD), following treatment with 5-aza-dC to induce DNA demethylation. These results provide insight into the role of epigenetic alterations, spec...
ORGANISM(S): Homo sapiens 
2010-10-07 | E-GEOD-18454 | biostudies-arrayexpress
TranscriptomicsGENOME-WIDE CpG ISLAND METHYLATION ANALYSIS IN NON-SMALL CELL LUNG CANCER PATIENTS [Affymetrix expression data]
Epigenetic changes largely contribute to the regulation of gene expression in cancer cells. DNA methylation is part of the epigenetic gene regulation complex which is relevant for the pathogenesis of cancer. We performed a genome-wide search for methylated CpG islands in tumors and corresponding non...
ORGANISM(S): Homo sapiens 
2012-11-26 | E-GEOD-32496 | biostudies-arrayexpress
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