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MetabolomicsDistinct metabolic profiles in lung adenocarcinomas presenting as solid or ground-glass opacities

Metabolomic profiling provides real-time insights into tissue physiology and upstream molecular events. Despite its potential in cancer research, large-scale integrative studies in lung adenocarcinoma (LUAD) remain scarce. We analyzed 262 tissue samples from 165 LUAD patients using metabolomic, t...

2025-12-23 | MTBLS13565 | MetaboLights
TranscriptomicsUnique microRNA profiles in EGFR-mutated lung adenocarcinomas
We have examined the microRNA expression in 154 lung adenocarcinoma samples and 20 paired normal lung tissue samples and investigated the microRNA expression to clinical variables, EGFR- and KRAS- mutational status and time to progression. 174 samples are analyzed. 154 from lung adenocarcinoma tumor...
ORGANISM(S): Homo sapiens 
2014-03-10 | E-GEOD-48414 | biostudies-arrayexpress
TranscriptomicsSmoking Status Impacts microRNA Mediated Prognosis and Lung Adenocarcinoma Biology
Cigarette smoke is associated with the majority of lung cancers: however, 25% of lung cancer patients are non-smokers, and half of all newly diagnosed lung cancer patients are former smokers. Lung tumors exhibit distinct epidemiological, clinical, pathological, and molecular features depending on sm...
ORGANISM(S): Homo sapiens 
2014-10-30 | E-GEOD-62182 | biostudies-arrayexpress
TranscriptomicsMolecular profiling of primary lung carcinomas
This SuperSeries is composed of the following subset Series: GSE29016: Relation between smoking history and gene expression profiles in lung adenocarcinomas GSE29065: Landscape of somatic allelic imbalances and copy number alterations in human lung carcinoma Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-10-09 | E-GEOD-29066 | biostudies-arrayexpress
TranscriptomicsSpheres culture from lung adenocarcinoma pleural effusions
Briefly, we analyzed gene expression profiles in adherent cultures compared to sphere cultures from malignant pleural effusions (MPEs). MPEs could represent an opportunity to culture a wide variety of cancer cells from different donors. In this study, we set up culture conditions for cancer cells de...
ORGANISM(S): Homo sapiens 
2011-12-02 | E-MEXP-3025 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lung adneocarcinomas - discovery of somatic mutations in lung adenocarcinomas
This was a collaborative study to discover somatic mutations in 188 lung adenocarcinomas. DNA sequencing of 623 genes with known or potential relationships to cancer revealed more than 1,000 somatic mutations across the samples. Our analysis identified 26 genes that are mutated at significantly high...
ORGANISM(S): Homo sapiens 
2009-09-11 | E-GEOD-12667 | biostudies-arrayexpress
TranscriptomicscaArray_meyer-00191: Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses
We have generated a molecular taxonomy of lung carcinoma, the leading cause of cancer death in the United States and worldwide. Using oligonucleotide microarrays, we analyzed mRNA expression levels corresponding to 12,600 transcript sequences in 186 lung tumor samples, including 139 adenocarcinomas ...
ORGANISM(S): Homo sapiens 
2016-06-11 | E-GEOD-83227 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of lung adenocarcinomas and normal lung tissue
Lung cancer is still the leading cause of cancer-related deaths in the US and worldwide. Understanding the global molecular profiles or transcriptome of lung cancers would strengthen our understanding of the biology of this malignancy. We performed gene expression profiling using the Human Gene 1.0 ...
ORGANISM(S): Homo sapiens 
2013-08-06 | E-GEOD-43458 | biostudies-arrayexpress
TranscriptomicsADAM-28: A potential oncogene involved in asbestos-related lung adenocarcinomas
To identify gene expression biomarkers associated with asbestos-related lung adenocarcinoma, we analyzed primary tumour gene expression for a total of 36 primary lung adenocarcinomas on 22,323 element microarrays, comparing 12 patients with lung asbestos body counts above levels associated with urba...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-20875 | biostudies-arrayexpress
GenomicsNkx2-1 Represses a Latent Gastric Differentiation Program in Lung Adenocarcinoma
Tissue-specific differentiation programs become dysregulated during cancer evolution. The transcription factor Nkx2-1 is a master regulator of pulmonary differentiation that is downregulated in poorly differentiated lung adenocarcinoma. Here we use conditional murine genetics to study the fate of l...
ORGANISM(S): Mus musculus 
2013-04-09 | E-GEOD-43252 | biostudies-arrayexpress
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