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TranscriptomicsTranscription profiling of human lung adneocarcinomas - discovery of somatic mutations in lung adenocarcinomas
This was a collaborative study to discover somatic mutations in 188 lung adenocarcinomas. DNA sequencing of 623 genes with known or potential relationships to cancer revealed more than 1,000 somatic mutations across the samples. Our analysis identified 26 genes that are mutated at significantly high...
ORGANISM(S): Homo sapiens 
2009-09-11 | E-GEOD-12667 | biostudies-arrayexpress
TranscriptomicsWhole-genome gene expression profiles of non-tumorous human lung tissues
This SuperSeries is composed of the following subset Series: GSE23352: Whole-genome gene expression profiles of non-tumorous human lung tissues: Laval set GSE23529: Whole-genome gene expression profiles of non-tumorous human lung tissues: UBC set GSE23545: Whole-genome gene expression profiles of no...
ORGANISM(S): Homo sapiens 
2012-06-10 | E-GEOD-23546 | biostudies-arrayexpress
TranscriptomicsWhole-genome gene expression profiles of non-tumorous human lung tissues: GRNG set
We profiled genome-wide gene expression in non-tumorous human lung tissues. The overall goal of this project is to improve our molecular understanding of various lung diseases including lung cancer and chronic obstructive pulmonary disease (COPD). Lung specimens were obtained from patients with a va...
ORGANISM(S): Homo sapiens 
2012-06-10 | E-GEOD-23545 | biostudies-arrayexpress
TranscriptomicsWhole-genome gene expression profiles of non-tumorous human lung tissues: Laval set
We profiled genome-wide gene expression in non-tumorous human lung tissues. The overall goal of this project is to improve our molecular understanding of various lung diseases including lung cancer and chronic obstructive pulmonary disease (COPD). Lung specimens were obtained from patients undergoin...
ORGANISM(S): Homo sapiens 
2012-06-10 | E-GEOD-23352 | biostudies-arrayexpress
TranscriptomicsWhole-genome gene expression profiles of non-tumorous human lung tissues: UBC set
We profiled genome-wide gene expression in non-tumorous human lung tissues. The overall goal of this project is to improve our molecular understanding of various lung diseases including lung cancer and chronic obstructive pulmonary disease (COPD). The samples from the University of British Columbia ...
ORGANISM(S): Homo sapiens 
2012-06-10 | E-GEOD-23529 | biostudies-arrayexpress
Transcriptomicsexpression data in lung of mice bearing inducible FGF18 transgene
Better understanding alveolarization mechanisms could help improving prevention and treatment of diseases characterized by reduced alveolar number, especially bronchopulmonary dysplasia (BPD). Although signaling through fibroblast growth factor (FGF) receptors is essential for alveolarization, invol...
ORGANISM(S): Mus musculus 
2011-07-05 | E-GEOD-22283 | biostudies-arrayexpress
TranscriptomicsMiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer from never-smokers
Approximately 15% of lung cancer cases are not associated with smoking and show molecular and clinical characteristics distinct from those in smokers. Epidermal growth factor receptor (EGFR) gene mutations, which are correlated with sensitivity to EGFR-tyrosine kinase inhibitors (EGFR-TKIs), are mo...
ORGANISM(S): Homo sapiens 
2010-05-15 | E-GEOD-14936 | biostudies-arrayexpress
UnknownStem cell-based Lung-on-Chips: The best of both worlds?
Not available
S-EPMC7172977 | biostudies-literature
TranscriptomicsA spatial multi-omics atlas of the human lung reveals a novel immune cell survival niche - Visium
Multiple distinct cell types of the human lung and airways have been defined by single cell RNA sequencing (scRNAseq). Here we present a multi-omics spatial lung atlas to define novel cell types which we map back into the macro- and micro-anatomical tissue context to define functional tissue microen...
ORGANISM(S): Homo sapiens 
2022-01-06 | E-MTAB-11640 | biostudies-arrayexpress
TranscriptomicsOpen lung approach with low tidal volume mechanical ventilation attenuates lung injury in rats with massive brain damage
Introduction: The ideal ventilation strategy for patients with massive brain damage requires better elucidation. We hypothesized that in the presence of massive brain injury, a ventilation strategy using low (6 mL/kg) tidal volume (VT) ventilation with open lung positive end-expiratory pressure set ...
ORGANISM(S): Rattus norvegicus 
2014-04-24 | E-GEOD-52142 | biostudies-arrayexpress
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