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MetabolomicsMulti-omics Analysis Reveals New Insights into Yak Lung Fibrosis Mechanisms Under High-Altitude Adaptation

The lung of yak is an important adaptive organ in the cold and low oxygen environment. Hypoxia can induce the pathological manifestations of pulmonary fibrosis in yak, but there was no study on hypoxia induced pulmonary fibrosis in yak. In this study full target metabolomics were used to conduct ...

2025-07-07 | MTBLS11648 | MetaboLights
MetabolomicsCombined metabolomics with transcriptomics reveals important serum biomarkers correlated with lung cancer proliferation through calcium signaling pathway

Lung cancer (LC) is still one of the most deadly cancers in the world, but there is a lack of non-invasive biomarkers to assist diagnosis and guide treatment. Herein, untargeted serum metabolomics of 57 LC patients and 59 HC people was performed based on gas chromatography-mass spectrography (GC-...

2025-04-29 | MTBLS1517 | MetaboLights
MetabolomicsMulti-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke
Cigarette smoke (CS) causes adverse health effects and leads to the development of respiratory disease (chronic obstructive pulmonary disease), cardiovascular disease, and cancer. To reduce the risk of smokers developing smoking-related diseases, Philip Morris International is developing modified ri...
2020-04-25 | MTBLS158 | MetaboLights
TranscriptomicsCigarette smoke-induced iBALT mediates macrophage activation in a B cell-dependent manner in COPD
Chronic obstructive pulmonary disease (COPD) is characterized by a progressive decline in lung function, caused by exposure to exogenous particles, mainly cigarette smoke (CS). COPD pathogenesis is initiated and perpetuated by an abnormal CS-induced inflammatory response of the lungs, involving both...
ORGANISM(S): Mus musculus 
2014-12-04 | E-GEOD-52509 | biostudies-arrayexpress
TranscriptomicsEffect of 48 h aldosterone treatment on late-gestation fetal lung
The late-gestation fetal lung has relatively high levels of expression of the mineralocorticoid receptor (MR) as well as the glucocorticoid receptor (GR), suggesting that endogenous corticosteroids may act in the lung through binding at MR as well as GR. This study was designed to determine the effe...
ORGANISM(S): Ovis aries 
2014-08-07 | E-GEOD-53048 | biostudies-arrayexpress
ProteomicsGlobal Matrisome changes in the obese lung are linked to fibroblastic stroma and premature aging
Obesity is associated with an increased risk of lung disorders, yet its effects on lung tissue structure and the microenvironment remain incompletely understood. Using a multiomics strategy combining tissue proteomics, lipidomics, solubility profiling, single-cell transcriptomics, and functional ass...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-21 | PXD064681 | Pride
Mouse Lung Obesity 
UnknownmTORC1 is a mechanosensor that regulates surfactant function and lung compliance during ventilator-induced lung injury.
Not available
S-EPMC8410036 | biostudies-literature
UnknownLung Cancer Risk in Men and Compliance with the 2018 WCRF/AICR Cancer Prevention Recommendations.
Not available
S-EPMC9607029 | biostudies-literature
UnknownMechanical power normalized to lung-thorax compliance indicates weaning readiness in prolonged ventilated patients.
Not available
S-EPMC8741981 | biostudies-literature
UnknownMechanical power normalized to lung-thorax compliance predicts prolonged ventilation weaning failure: a prospective study.
Not available
S-EPMC8210735 | biostudies-literature
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