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TranscriptomicsExpression data from (mouse) normal lung fibroblasts and carcinoma-associated fibroblasts
Cancer-associated fibroblasts (CAFs) have been reported to support tumor progression by a variety of mechanisms. However, their role in the progression of non-small cell lung cancer (NSCLC) remains poorly defined. In addition, the extent to which specific proteins secreted by CAFs contribute directl...
ORGANISM(S): Mus musculus 
2013-07-10 | E-GEOD-48397 | biostudies-arrayexpress
TranscriptomicsGenomic differences distinguish the myofibroblast phenotype of distal lung from airway fibroblasts
ABSTRACT Primary human distal lung/parenchymal fibroblasts (DLF) exhibit a different phenotype from airway fibroblasts (AF), including the expression of high levels of a-smooth muscle actin (a-SMA). The scope of the differences and the mechanisms driving them are unknown. To determine whether disti...
ORGANISM(S): Homo sapiens 
2011-07-21 | E-GEOD-27335 | biostudies-arrayexpress
TranscriptomicsDissection of human fibroblast populations by lung regions: genomic differences and functional pathway analysis
ABSTRACT Background: Primary human distal lung/parenchymal fibroblasts (DLF) exhibit a different phenotype from airway fibroblasts (AF), including the expression of high levels of alpha-SMA. The scope of the differences and the mechanisms driving them are unknown. We hypothesized that the distinct ...
ORGANISM(S): Homo sapiens 
2011-07-21 | E-GEOD-19362 | biostudies-arrayexpress
TranscriptomicsExpression data from cultured human lung tissue-derived fibroblasts and human vascular adventitial fibroblasts
In order to find the difference between human lung tissue-derived fibroblasts and human vascular adventitial fibroblasts for enhancing tumor formation ablity of human lung adenocarcinoma cell line A549, we found that human vascular adventitial fibroblasts enhance A549 tumor formation in vivo compare...
ORGANISM(S): Homo sapiens 
2010-12-18 | E-GEOD-26146 | biostudies-arrayexpress
TranscriptomicsGene expression in lung fibroblasts
Pulmonary fibrosis is a chronic, progressive, and lethal interstitial lung disease. It is characterized by extracellular matrix deposition, fibroblast proliferation, and accumulation. Fibroblasts from normal or UIP histology were cultured and analyzed. Keywords: Fibroblasts from normal histology lun...
ORGANISM(S): Homo sapiens 
2010-06-21 | E-GEOD-10921 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat lung alveolar development
Lung alveolarization is a complex process that involves interactions between several cell types and leads to considerable increase in gas-exchange surface area. The step designated secondary septation includes elastogenesis from interstitial fibroblasts. We used microarrays to detail the global prog...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-7491 | biostudies-arrayexpress
TranscriptomicsExpression profiles of immortal lung fibroblasts
Activation of telomerase often endows cancer cells, but rarely normal somatic cells, with immortality. Especially, fetal lung fibroblasts are known to be hardly immortalized by TERT overexpression. We here established an immortal non-transformed lung fibroblast cell line only by TERT transfection, a...
ORGANISM(S): Homo sapiens 
2010-05-22 | E-GEOD-9077 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cancer-associated fibroblasts treated with dasatinib
Effect of Dasatinib on primary cancer-associated fibroblasts from lung cancer specimens.
ORGANISM(S): Homo sapiens 
2011-01-12 | E-MEXP-2546 | biostudies-arrayexpress
TranscriptomicsIdentification of the gene expression in IPF lung fibroblasts after demethylation
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease. Although the pathogenesis is poorly understood, evidence suggests that genetic and epigenetic alterations, such as DNA methylation, may play a key role. We used microarrays to see the gene expression in IPF fibroblasts after demethyl...
ORGANISM(S): Homo sapiens 
2016-02-16 | E-GEOD-69764 | biostudies-arrayexpress
TranscriptomicsmiRNA in human lung fibroblasts
By employing miRCURY™ LNA array, we have identified a subset (79) of the total number of miRNAs that are differentially expressed in TGF beta1-treated human lung fibroblasts MRC-5 cells, as compared to untreated control cells To know the differential expression of miRNA in human lung fibroblasts aft...
ORGANISM(S): Homo sapiens 
2013-02-01 | E-GEOD-43992 | biostudies-arrayexpress
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