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MetabolomicsA blood-based metabolic signature for earlier detection of lung cancer

Metabolomic profiling was applied to 1,259 sera collected within five years of a lung cancer diagnosis and 8,470 non-case sera from ever-smoker participants in the Prostate Lung Colorectal and Ovarian (PLCO) Study to identify metabolic signatures for the earlier detection of lung cancer. We devel...

2026-08-20 | MTBLS15406 | MetaboLights
Transcriptomicsp63+/Krt5+ Distal Airway Stem Cells are Essential for Lung Regeneration (transplanted and damaged)
The possibility of lung regeneration has been long discounted due to the irreversible nature of chronic lung diseases. However, patients who sustain massive loss of lung tissue during acute infections often recover full pulmonary function. Correspondingly, we previously demonstrated lung regenerat...
ORGANISM(S): Mus musculus 
2014-11-20 | E-GEOD-60830 | biostudies-arrayexpress
Transcriptomicsp63+/Krt5+ Distal Airway Stem Cells are Essential for Lung Regeneration (Dtox treatment)
The possibility of lung regeneration has been long discounted due to the irreversible nature of chronic lung diseases. However, patients who sustain massive loss of lung tissue during acute infections often recover full pulmonary function. Correspondingly, we previously demonstrated lung regenerat...
ORGANISM(S): Mus musculus 
2014-11-20 | E-GEOD-60829 | biostudies-arrayexpress
Transcriptomicsp63+/Krt5+ Distal Airway Stem Cells are Essential for Lung Regeneration (before and after in vitro differentiation)
The possibility of lung regeneration has been long discounted due to the irreversible nature of chronic lung diseases. However, patients who sustain massive loss of lung tissue during acute infections often recover full pulmonary function. Correspondingly, we previously demonstrated lung regenerat...
ORGANISM(S): Mus musculus 
2014-11-20 | E-GEOD-60828 | biostudies-arrayexpress
Transcriptomicsp63+/Krt5+ Distal Airway Stem Cells are Essential for Lung Regeneration (tracheal epithelium and alveoli)
The possibility of lung regeneration has been long discounted due to the irreversible nature of chronic lung diseases. However, patients who sustain massive loss of lung tissue during acute infections often recover full pulmonary function. Correspondingly, we previously demonstrated lung regenerat...
ORGANISM(S): Mus musculus 
2014-11-20 | E-GEOD-61091 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of pulmonary alveoli from calorie-restricted mice at different timepoints to study the molecular mechanism of alveoli loss.
Pulmonary alveoli are complex architectural units thought to undergo endogenous or pharmacologically induced programs of regeneration and degeneration. To study the molecular mechanism of alveoli loss mice were calorie restricted at different timepoints. Lungs were harvested and processed for RNA ex...
ORGANISM(S): Mus musculus 
2007-11-06 | E-GEOD-478 | biostudies-arrayexpress
ProteomicsMechanical tension-induced spatial control of angiogenesis during lung regeneration
Mechanical forces altered after unilateral pneumonectomy (PNX) control post-PNX lung growth. Here we demonstrate that post-PNX vascular formation is stimulated at the peripheral region of the mouse lung requiring focal adhesion protein, paxillin, while inhibition of mechanical tension attenuates the...
ORGANISM(S): Mus musculus (Mouse) 
2026-10-19 | PXD038600 | Pride
Angiogenesis Angiopoietins Lung regeneration Paxillin Mechanical tension 
Transcriptomicsp63+/Krt5+ Distal Airway Stem Cells are Essential for Lung Regeneration
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-11-20 | E-GEOD-60849 | biostudies-arrayexpress
TranscriptomicsAge-dependent decline in lung regeneration with loss of clonogenicity and myofibroblastic differentiation of lung fibroblasts
While aging leads to a reduction in the capacity for regeneration after pneumonectomy (PNX) in most mammals, this biological phenomenon has not been characterized over the lifetime of mice. We measured the age-specific (3, 9, 24 month) effects of PNX on physiology, morphometry, cell proliferation an...
ORGANISM(S): Mus musculus 
2011-03-16 | E-GEOD-27964 | biostudies-arrayexpress
Proteomics,MultiomicsAlveolar Injury and Regeneration Following Deletion of ABCA3
Lipidomics and proteomics characterization of lipid and protein changes in BALF from ABCA3 knockout mice compared to control.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-08-22 | MSV000081473 | MassIVE
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