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UnknownDeveloping a synergistic rate-retarding polymeric implant for controlling monoclonal antibody delivery in minimally invasive glaucoma surgery.
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S-EPMC11780753 | biostudies-literature
ProteomicsNBS1 facilitates pre-ribosomal RNA biogenesis
Mutations of NBS1 gene result in Nijmegen breakage syndrome (NBS), and the gene encodes NBS1 that forms a complex with MRE11 and RAD50 and participates in DNA damage repair. However, the molecular mechanism by which the mutations of NBS1 cause clinical phenotypes of NBS, such as craniofacial dysmorp...
ORGANISM(S): Homo sapiens (Human) 
2025-09-15 | PXD056042 | Pride
Pre-ribosomal rna Nbs1 Nucleolus 
GenomicsDynamic Reorganization of the Cardiomyocyte Transcriptome in Response to TNFM-NM-1-induced Proinflammatory Signaling [ChIP-Seq]
Inflammation is associated with many cardiovascular pathologies, but the underlying mechanisms remain unclear. To explore this in more detail, we characterized the transcriptome of an immortalized adult human ventricular cardiomyocyte cell line (AC16) in response to tumor necrosis factor (TNFa). U...
ORGANISM(S): Homo sapiens 
2014-02-27 | E-GEOD-51169 | biostudies-arrayexpress
TranscriptomicsSignaling Pathways Deferentially Affect RNA Polymerase II Initiation, Pausing, and Elongation in Human Cells: Estrogen dependent signaling in MCF-7 cells
We used Global Run-on and Sequencing (GRO-seq) to measure the rate of transcription elongation by RNA polymerase II (Pol II) following gene activation. We observed that Pol II elongation rates can vary as much as 4-fold at different genomic loci and in response to two distinct cellular signaling pa...
ORGANISM(S): Homo sapiens 
2013-04-10 | E-GEOD-41324 | biostudies-arrayexpress
TranscriptomicsEstrogen-Related Receptor M-NM-3 (ERRM-NM-3) Regulates Oxygen-Dependent Expression of Voltage-gated Potassium (K+) Channels and Tissue Kallikrein during Human Trophoblast Differentiation
Estrogen-related receptor M-NM-3 (ERRM-NM-3) serves a critical O2-dependent regulatory role in differentiation of human cytotrophoblasts to syncytiotrophoblast. In this study, we investigated expression of genes encoding tissue kallikreins (KLK1) and voltage-gated K+ channels (KV7) during differenti...
ORGANISM(S): Homo sapiens 
2013-04-30 | E-GEOD-46463 | biostudies-arrayexpress
TranscriptomicsInhibition of Hedgehog Signaling Pathway Impairs Cancer Cell Growth via Promotion of Autophagy
Analysis of gene expression levels in response to inhibition of Hh signaling in ovarian and glioma cancer cells using a cDNA microarray technique. Microarray analyses revealed that differentially expressed genes (DEGs) in human cancer cells are enriched in the senescence and autophagy pathways in re...
ORGANISM(S): Homo sapiens 
2014-06-15 | E-GEOD-54936 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for NF1-associated glioma risk
We performed whole genome SNP profiling on DNA samples from 236 patients with NF1, 123 with glimoa tumors and 113 without; 117 females and 119 males, together with 29 control samples. To identify polymorphisms in human adenylate cyclase 8 (AC8) which correlate with glioma risk in NF1 in a sex-speci...
ORGANISM(S): Homo sapiens 
2015-02-20 | E-GEOD-62215 | biostudies-arrayexpress
TranscriptomicsGene expression data at 24hrs post-siRNA transfection for HCT116 cultures transfected with either DDX5si2008, DDX5si2053, or EBNA1si1666 siRNA's or mock transfected.
HCT116 cells were transfected with two different siRNA's targeting either DDX5, an siRNA targeting EBNA1, or no siRNA (mock). The siRNA targeting EBNA1 is used as a negative control since HCT116 cells do not have the EBNA1 gene. RNA was obtained from cultures at 24hrs post-siRNA transfection using t...
ORGANISM(S): Homo sapiens 
2012-06-01 | E-GEOD-36141 | biostudies-arrayexpress
TranscriptomicslncRNA expression profiles for preterm premature rupture of membrane (PPROM)
Investigation of lncRNA expression profile of PPROM Arraystar Human LncRNA Array v2.0 was applied to study 40 placentas.
ORGANISM(S): Homo sapiens 
2013-12-18 | E-GEOD-50879 | biostudies-arrayexpress
GenomicsChip-Seq of human jurkat cell line to investigate genome-wide mapping of in vivo protein-DNA interactions
In vivo protein-DNA interactions connect each transcription factor with its direct targets to form a gene network scaffold. To map these protein-DNA interactions comprehensively across entire mammalian genomes, we developed a large-scale chromatin immunoprecipitation assay (ChIPSeq) based on direct ...
ORGANISM(S): Homo sapiens 
2009-08-29 | E-GEOD-13047 | biostudies-arrayexpress
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