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ProteomicsNBS1 facilitates pre-ribosomal RNA biogenesis
Mutations of NBS1 gene result in Nijmegen breakage syndrome (NBS), and the gene encodes NBS1 that forms a complex with MRE11 and RAD50 and participates in DNA damage repair. However, the molecular mechanism by which the mutations of NBS1 cause clinical phenotypes of NBS, such as craniofacial dysmorp...
ORGANISM(S): Homo sapiens (Human) 
2025-09-15 | PXD056042 | Pride
Pre-ribosomal rna Nbs1 Nucleolus 
TranscriptomicsMRE11-RAD50-NBS1 activates Fanconi Anemia R-loop suppression at transcription-replication conflicts
Rad50 is a component of the conserved MRE11-RAD50-NBS1 (MRN) complex, which functions in genome stability and the cell’s ability to deal with stalled DNA replication forks. We identified Rad50 as a factor important for R-loop tolerance and thus mapped DNA:RNA hybrids in Rad50KO cells and compare the...
ORGANISM(S): Saccharomyces cerevisiae 
2019-10-31 | E-MTAB-7885 | biostudies-arrayexpress
GenomicsGenome-wide expression analysis in murine liver after Nbs1 induced knockout
Genome-wide expression analysis in murine liver after Nbs1 induced knockout
PRJNA565740 | ENA
ProteomicsNBS1 facilitates pre-ribosomal RNA biogenesis
Mutations of NBS1 gene result in Nijmegen breakage syndrome (NBS), and the gene encodes NBS1 that forms a complex with MRE11 and RAD50 and participates in DNA damage repair. However, the molecular mechanism by which the mutations of NBS1 cause clinical phenotypes of NBS, such as craniofacial dysmorp...
ORGANISM(S): Homo Sapiens 
2025-02-24 | PXD061157 |
ProteomicsPPARG interactions with UBR5 and MRE11-RAD50-NBS1 are required for DNA damage response and repair.
PPARG interactome datasets containing (1) Flag-PPARG AP-MS, identifying MRE11, RAD50 and NBS1 as novel interactors, (2) tandem-IP (in solution and silver fragments) of PPARG-Strep and Flag-NBS1, which identifies PPARG interaction with UBR5 (3) tandem-IP (same as 2) with BS3 cross-linking illustrates...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-12-18 | MSV000083257 | MassIVE
TranscriptomicsGenome-wide expression analysis in murine liver after Nbs1 induced knockout
NBS1 (Nbn in Mus musculus) is a critical component of the MRN (MRE11/RAD50/NBS1) complex, which regulates ATM- and ATR-mediated DNA damage response (DDR) pathways. NBS1 mutations cause the human genomic instability syndrome Nijmegen Breakage Syndrome (NBS), in which microcephaly and intellectual dis...
ORGANISM(S): Mus musculus 
2022-09-16 | GSE137505 | GEO
UnknownNBS1 facilitates preribosomal RNA biogenesis.
Not available
S-EPMC11929472 | biostudies-literature
UnknownNBS1 Heterozygosity and Cancer Risk.
Not available
S-EPMC2682932 | biostudies-literature
UnknownNBS1 binds directly to TOPBP1 via disparate interactions between the NBS1 BRCT1 domain and the TOPBP1 BRCT1 and BRCT2 domains.
Not available
S-EPMC9992324 | biostudies-literature
UnknownNBS1 interacts with Notch signaling in neuronal homeostasis.
Not available
S-EPMC7641754 | biostudies-literature
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