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TranscriptomicsExpression profile of the endocrine therapy sensitive breast cancer cells MCF7 depleted of PBX1
Effect of PBX1 silencing on global gene expression of MCF7 cells stimulated with EGF. The hypothesis tested was that PBX1 is essential for EGF signaling in ERa positive breast cancer cells. Total RNA was obtained from MCF7 cells treated with siRNA directed at PBX1 or an siControl for 72h. Cells were...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-39417 | biostudies-arrayexpress
TranscriptomicsThe Chromatin-Looping Factor ZNF143 Engages at Looping Promoters to Favor the Estrogen Response in Breast Cancer
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-08-09 | E-GEOD-76460 | biostudies-arrayexpress
GenomicsThe histone variant H2A.Z is an important regulator of enhancer activity.
Gene regulatory programs in different cell types are largely defined through cell-specific enhancers activity. The histone variant H2A.Z has been shown to play important roles in transcription mainly by controlling proximal promoters, but its effect on enhancer functions remains unclear. Here, we de...
ORGANISM(S): Homo sapiens 
2015-08-31 | E-GEOD-57436 | biostudies-arrayexpress
GenomicsEpigenetic determinants of self-renewal in glioblastoma
We over-expressed an epigenetic regulator in a glioblastoma (GBM) primary culture from an adult patient. These GBM cells have cancer stem cell phenotypes, as they have self-renewal properties and tumor initiation potential when transplanted in immunocompromised mice. ATAC-seq was performed on cells ...
ORGANISM(S): Homo sapiens 
2015-12-08 | E-GEOD-67633 | biostudies-arrayexpress
UnknownIdentification of differentially expressed genes in uveal melanoma using suppressive subtractive hybridization.
Not available
S-EPMC3107995 | biostudies-literature
TranscriptomicsNoncoding somatic and inherited single-nucleotide variants converge to promote ESR1 expression in breast cancer
Sustained expression of the estrogen receptor-α (ESR1) drives two-thirds of breast cancer and defines the ESR1-positive subtype. ESR1 engages enhancers upon estrogen stimulation to establish an oncogenic expression program1. Somatic copy number alterations involving the ESR1 gene occur in approxima...
ORGANISM(S): Homo sapiens 
2016-08-23 | E-GEOD-74718 | biostudies-arrayexpress
GenomicsThe Chromatin-Looping Factor ZNF143 Engages at Looping Promoters to Favor the Estrogen Response in Breast Cancer (ChIP-seq)
Estrogen signaling in breast cancer cells relies on long-range chromatin interactions connecting distal regulatory elements bound by the estrogen receptor 1 (ESR1) to target gene promoters. This ensures stimulus and subtype-specific transcriptional responses. Expanding on the function of CTCF and th...
ORGANISM(S): Homo sapiens 
2016-08-09 | E-GEOD-76454 | biostudies-arrayexpress
GenomicsThe pioneer factor PBX1 guides a distinct ERa signaling in breast cancer [ChIP-seq]
We profiled global PBX1 binding in MCF7 cells. The hypothesis tested was that PBX1 binds regions that recruit ERa following estradiol stimulation. Profiling of PBX1 cistrome in MCF7 breast cancer cells
ORGANISM(S): Homo sapiens 
2011-09-29 | E-GEOD-28007 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of human Hela cells grown under serum starved condtions to identify new targets genes for ETS-domain transcription factor Elk-1
Chromatin immunoprecipitation coupled with microarray analysis (ChIP-chip) was carried out to identify new target genes for ETS-domain transcription factor Elk-1. Experiment was done in Hela cells under serum starved conditions.
ORGANISM(S): Homo sapiens 
2009-08-11 | E-MEXP-1527 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of human HeLa cells grown under serum starved conditions to identify new target genes for ETS-domain transcription factor Elk-1
Chromatin immunoprecipitation coupled with microarray analysis (ChIP-chip) was carried out to identify new target genes for ETS-domain transcription factor Elk-1. Experiment was done in Hela cells under serum starved conditions.
ORGANISM(S): Homo sapiens 
2009-08-11 | E-MEXP-2084 | biostudies-arrayexpress
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