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TranscriptomicsGene expression analysis in cortex of CRTC1 deficient mice and WT littermates
To identify gene expression changes associated with Crtc1 deficiency, we performed genome-wide transcriptome profile analyses by using mouse cDNA microarrays in the cortex of Crtc1‒/‒ and WT female mice BACKGROUND: Recent studies involve the arginine-decarboxylation product agmatine in mood regu...
ORGANISM(S): Mus musculus 
2016-07-18 | E-GEOD-80633 | biostudies-arrayexpress
TranscriptomicsLymphocyte gene expression data from moderate stage HD patients and controls
Highly quantitative biomarkers of neurodegenerative disease remain an important need in the urgent quest for disease modifying therapies. For Huntington's disease (HD), a genetic test is available (trait marker), but necessary state markers are still in development. In this report, we describe a lar...
ORGANISM(S): Homo sapiens 
2007-08-15 | E-GEOD-8762 | biostudies-arrayexpress
TranscriptomicsGene expression data from mouse HDAC4 KO pups, postnatal day 3
Reversible protein acetylation provides a central mechanism for controlling gene expression and cellular signaling events. It is governed by the antagonistic commitment of two enzymes families: the histone acetyltransferases (HATs) and the histone deacetylases (HDACs). HDAC4, like its class IIa coun...
ORGANISM(S): Mus musculus 
2014-07-30 | E-GEOD-49383 | biostudies-arrayexpress
TranscriptomicsGene expression from primary brain cell cultures and RNA mixtures.
Gene expression from primary neuronal, astrocytic, oligodendrocytic and microglial cultures, as well as from RNA mixtures thereof. Keywords: Primary cell cultures Primary neuronal, astrocytic, oligodendrocytic and microglial cultures (4 biological replicates of each), as well as RNA mixtures thereo...
ORGANISM(S): Rattus norvegicus 
2010-12-01 | E-GEOD-19380 | biostudies-arrayexpress
TranscriptomicsGene expression data from cortex of 9 week old wild type, R6/2, HDAC4het and R6/2::HDAC4het mice
Histone deacetylase (HDAC) 4 is a transcriptional repressor that contains a glutamine rich domain. We hypothesised that it may be involved in the molecular pathogenesis of Huntington's disease (HD), a protein folding neurodegenerative disorder caused by an aggregation-prone polyglutamine expansion a...
ORGANISM(S): Mus musculus 
2014-10-10 | E-GEOD-38218 | biostudies-arrayexpress
TranscriptomicsGene expression data from cortex of 15 week old wild type, R6/2, HDAC4het and R6/2::HDAC4het mice
Histone deacetylase (HDAC) 4 is a transcriptional repressor that contains a glutamine rich domain. We hypothesised that it may be involved in the molecular pathogenesis of Huntington's disease (HD), a protein folding neurodegenerative disorder caused by an aggregation-prone polyglutamine expansion a...
ORGANISM(S): Mus musculus 
2014-10-10 | E-GEOD-38219 | biostudies-arrayexpress
TranscriptomicsTranscruption profiling of human cerebellum, frontal cortex [BA4, BA9] and caudate nucleus HD tissue experiment
Post mortem human brain tissue comparison between HD patients and controls from 3 brain regions - cerebellum, frontal cortex [BA4, BA9] and caudate nucleus. Gene expression analysed using linear models from LIMMA package in Bioconductor suite. Experiment Overall Design: Large sample sizes were used...
ORGANISM(S): Homo sapiens 
2009-09-12 | E-GEOD-3790 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse striatal samples from wildtype, Hdh/Q80 animals
This SuperSeries is composed of the following subset Series:; GSE9375: Striatal gene expression data from 12 months-old Hdh4/Q80 mice and control mice. GSE9857: Striatal gene expression data from 12 weeks-old R6/2 mice and control mice; GSE10202: Striatal gene expression data from 22-month-old CHL2 ...
ORGANISM(S): Mus musculus 
2008-05-21 | E-GEOD-10263 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of striatal samples from 4 CHL2 Q150/Q150 mutant mice and 4 age-matched wild-type mice to investigate the study of huntingtin toxicity and its remedy in model systems.
Achieving a mechanistic understanding of disease and initiating preclinical therapeutic trials necessitate the study of huntingtin toxicity and its remedy in model systems. To allow the engagement of appropriate experimental paradigms, Huntington’s disease (HD) models need to be validated in terms...
ORGANISM(S): Mus musculus 
2008-04-10 | E-GEOD-10202 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse striatum from 3- and 18-month-old Q92 vs. control animals
Achieving a mechanistic understanding of disease and initiating preclinical therapeutic trials necessitate the study of huntingtin toxicity and its remedy in model systems. To allow the engagement of appropriate experimental paradigms, Huntington’s disease (HD) models need to be validated in terms...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7958 | biostudies-arrayexpress
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