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TranscriptomicsIdentification of the molecular targets of microRNA-181d in murine thymocytes.
T cell-specific transgenic expression of microRNA-181d reduced number of immature CD4+CD8+ thymocytes. Microarray analysis was performed to reveal differentially expressed genes between the wild type and microRNA-181d transgenic thymocytes. Whole thymus tissues were isolated from the wild type (C57B...
ORGANISM(S): Mus musculus 
2014-01-21 | E-GEOD-51778 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of normal and cancerous human breast samples
To assess changes in DNA methylation state associated with breast cancer we analyzed DNA from normal and cancerous breast specimens on CpG islands microarray using methylation-sensitive enzyme McrBC for target preparation. Cy3 was used for McrBC cut sample, Cy5 was used for reference Mock sample.
ORGANISM(S): Homo sapiens 
2006-11-03 | E-MEXP-881 | biostudies-arrayexpress
TranscriptomicsPromoter H3K4 methylation reveals the dynamic reinforcement of activation-induced pathways in human CD4 T cells with differential kinetics in naïve and memory cells (RNA-Seq)
The epigenetic determinants driving the rapid responses of memory CD4 T cells to antigen are currently an area of active research. While much has been done to characterize various Th subsets and their associated genome-wide epigenetic patterns, the dynamics of histone modifications during CD4 T cel...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-73213 | biostudies-arrayexpress
TranscriptomicsGene expression comparison of microRNA-181d Transgenic and microRNA-181d Knock-in thymocytes
T cell-specific over-expression of microRNA-181d reduced number of immature CD4+CD8+ thymocytes. Whole thymus tissues were isolated from the miR-181d transgenic (Tg-8) and miR-181d knockin (KI) mice, followed by total RNA isolation.
ORGANISM(S): Mus musculus 
2014-02-20 | E-GEOD-50113 | biostudies-arrayexpress
GenomicsPromoter H3K4 methylation dynamically reinforces activation-induced pathways in human CD4 T cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-73214 | biostudies-arrayexpress
UnknownA new locus for X-linked dominant Charcot-Marie-Tooth disease (CMTX6) is caused by mutations in the pyruvate dehydrogenase kinase isoenzyme 3 (PDK3) gene.
Not available
S-EPMC3596851 | biostudies-literature
TranscriptomicsEffect of rBTNL2.Fc co-stimulation on murine CD4+ cells
Naïve T cell activation involves at least two signals from an antigen presenting cell (APC), one through the T cell receptor via interaction with APC peptide-MHC complexes and a second through interaction of CD28 with APC B7 ligands. Following activation, T cells up-regulate a host of other membran...
ORGANISM(S): Mus musculus 
2013-01-31 | E-GEOD-42385 | biostudies-arrayexpress
GenomicsPromoter H3K4 methylation dynamically reinforces activation-induced pathways in human CD4 T cells
The epigenetic determinants driving the rapid responses of memory CD4 T cells to antigen are currently an area of active research. While much has been done to characterize various Th subsets and their associated genome-wide epigenetic patterns, the dynamics of histone modifications during CD4 T cel...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-73212 | biostudies-arrayexpress
TranscriptomicsDigoxin and its derivatives suppress Th17 cell differentiation by antagonizing RORγt activity
CD4+ T helper lymphocytes that express interleukin-17 (Th17 cells) have critical roles in mouse models of autoimmunity, and there is mounting evidence that they also influence inflammatory processes in humans. Genome-wide association studies in humans have linked genes involved in Th17 cell differe...
ORGANISM(S): Mus musculus 
2011-03-28 | E-GEOD-27241 | biostudies-arrayexpress
UnknownmTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux.
Not available
S-EPMC6892261 | biostudies-literature
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