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MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
MetabolomicsDifferentially manufactured Arnica montana L. extracts mediate anti-inflammatory effects on human T cells via different signaling pathways

Arnica montana L. (Arnica) has a long history of use in treating inflammation and soft tissue injury, yet its immunomodulatory mechanisms remain largely unexplored. In this study, we investigated the effects of distinct Arnica extracts - derived from different plant parts (root or whole ...

2025-09-16 | MTBLS11351 | MetaboLights
MetabolomicsMycobacterium tuberculosis-derived linoleic acid increases regulatory T cell function to promote bacterial survival within macrophages

Regulatory T cells (Tregs) expand during Mycobacterium tuberculosis (Mtb) infection and suppress T cell mediated control. Whether Mtb actively contributes to this process is unclear. Here, using a genome-wide mutant library, we show that expression of Mtb Rv1272c, an ATP-binding cassette transpor...

2025-09-28 | MTBLS12875 | MetaboLights
ProteomicsProject Title: Proteome analysis of CD4+ T cell subsets
Functionally distinct CD4+ helper T (Th) cell subsets, such as Th1, Th2, Th17, and regulatory T cells (Treg), play a pivotal role in the host-defense against pathogen invasion and the pathogenesis of inflammatory disorders. In this project, DIA-MS-based proteome analysis was performed on naïve CD4+ ...
ORGANISM(S): Mus Musculus (mouse) 
2023-01-04 | PXD036065 | JPOST Repository
GenomicsEpigenetic profiling in CD4 and CD8 T cells from Gravesâ?? disease patients reveals changes in genes associated with T cell receptor signaling [ChIP-seq]
In Gravesâ?? disease (GD), a combination of genetic, epigenetic and environmental factors causes an autoimmune response to the thyroid gland, characterized by lymphocytic infiltrations and autoantibodies targeting the thyroid stimulating hormone receptor (TSHR) and other thyroid antigens. To identif...
ORGANISM(S): Homo sapiens 
2015-11-06 | E-GEOD-71952 | biostudies-arrayexpress
TranscriptomicsHDAC1/2 and CD4+ T cells
Dynamic changes in histone acetylation patterns are mediated by the activity of histone acetyltransfereases (HATs) and histone deacetylases (HDACs) and are key events in the epigenetic regulation of gene expression. The application of HDAC inhibitors revealed a variety of T cell functions controlled...
ORGANISM(S): Mus musculus 
2014-03-30 | E-MTAB-2184 | biostudies-arrayexpress
ProteomicsA Multi-Omic Analysis of Human Naive CD4 T cells
Technological advances in genomics, epigenomics, transcriptomics and proteomics have enabled massively parallel measurements across thousands of genes and gene products. Such high-throughput technologies have been extensively used to carry out genome-wide studies particularly in the context of disea...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-04-04 | MSV000079624 | MassIVE
TranscriptomicsEpigenetic profiling in CD4 and CD8 T cells from Graves’ disease patients reveals changes in genes associated with T cell receptor signaling [methylation]
In Graves’ disease (GD), a combination of genetic, epigenetic and environmental factors causes an autoimmune response to the thyroid gland, characterized by lymphocytic infiltrations and autoantibodies targeting the thyroid stimulating hormone receptor (TSHR) and other thyroid antigens. To identif...
ORGANISM(S): Homo sapiens 
2015-11-06 | E-GEOD-71955 | biostudies-arrayexpress
TranscriptomicsEpigenetic profiling in CD4 and CD8 T cells from Graves’ disease patients reveals changes in genes associated with T cell receptor signaling [gene expression]
In Graves’ disease (GD), a combination of genetic, epigenetic and environmental factors causes an autoimmune response to the thyroid gland, characterized by lymphocytic infiltrations and autoantibodies targeting the thyroid stimulating hormone receptor (TSHR) and other thyroid antigens. To identif...
ORGANISM(S): Homo sapiens 
2015-11-06 | E-GEOD-71956 | biostudies-arrayexpress
TranscriptomicsExpression data from Ly-6C- and Ly-6C+ Naive CD4 T cells
The naive CD4 T cell compartment is heterogeneous. Ly-6C- and Ly-6C+ Naive CD4 T cells were compare by microarrays. Ly-6C- and Ly-6C+ Naive CD4 T cells were purified for RNA extraction and hybridization on Affymetrix microarrays.
ORGANISM(S): Mus musculus 
2013-03-01 | E-GEOD-37336 | biostudies-arrayexpress
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