Sort   by:  
 Page size 
TranscriptomicsComparative in situ gene expression profile of starry-sky tumor-associated macrophages and germinal centre macrophages
Cells undergoing apoptosis are known to modulate their tissue microenvironments. By acting on phagocytes, notably macrophages, apoptotic cells inhibit immunological and inflammatory responses and promote trophic signaling pathways. Paradoxically because of their potential to cause death of tumor cel...
ORGANISM(S): Mus musculus 
2014-12-20 | E-GEOD-64366 | biostudies-arrayexpress
TranscriptomicsSingle-cell sequencing of tissue-resident CD4+ T cells that drive compartmentalized immunopathology in the CNS
In chronic inflammatory diseases of the central nervous system (CNS), immune cells persisting behind the blood-brain barrier are supposed to promulgate local tissue destruction. The drivers of such compartmentalized inflammation remain unclear, but tissue-resident memory T cells (TRM) represent a po...
ORGANISM(S): Mus musculus 
2022-02-19 | E-MTAB-11422 | biostudies-arrayexpress
TranscriptomicsSynergistic activation by p38MAPK and glucocorticoid signaling mediates induction of M2-like tumor-associated macrophages expressing the novel CD20 homolog MS4A8A.
Tumor-associated macrophages (TAMs) represent alternatively activated (M2) macrophages that support tumor growth. Previously, we have described a special LYVE-1(+) M2 TAM subset in vitro and in vivo; gene profiling of this TAM subset identified MS4A8A as a novel TAM molecule expressed in vivo by TAM...
ORGANISM(S): Mus musculus 
2012-05-22 | E-GEOD-38171 | biostudies-arrayexpress
TranscriptomicsSingle-cell sequencing of tissue-resident CD8+ T cells that drive compartmentalized immunopathology in the CNS
In chronic inflammatory diseases of the central nervous system (CNS), immune cells persisting behind the blood-brain barrier are supposed to promulgate local tissue destruction. The drivers of such compartmentalized inflammation remain unclear, but tissue-resident memory T cells (TRM) represent a po...
ORGANISM(S): Mus musculus 
2022-03-14 | E-MTAB-11511 | biostudies-arrayexpress
TranscriptomicsWhole genome transcriptome analysis of tumor-specific CD8 T cells in pre-malignant lesions
Gene expression analysis of tumor-specific CD8 T cells encountering a tumor-specific antigen in pre-malignant lesions in the liver at different time points post tumor initiation. The overall goal of this mouse study was to elucidate the molecular program in tumor-specific T cells encountering a tumo...
ORGANISM(S): Mus musculus 
2016-08-11 | E-GEOD-60501 | biostudies-arrayexpress
TranscriptomicsGene expression profile in a breast cancer cell line upon hormonal treatments
MCF-7 TET Off cells (MCF-7 wt) were used to produce stable clones expressing ER-alpha tagged with TAP-tag at the C-term (C-TAP-ER-alpha). All cells were grown in Dulbecco's modified Eagle's medium (DMEM), starved by using DMEM w/o phenol red and 5% Dextran Coated Charcoal stripped serum (DCC-FBS) fo...
ORGANISM(S): Homo sapiens 
2012-06-25 | E-MTAB-1196 | biostudies-arrayexpress
UnknownPharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia.
Not available
S-EPMC5374978 | biostudies-literature
TranscriptomicsCharacterization of A Novel CRAC Inhibitor that Potently Blocks Human T cell Activation and Effector Functions
Store operated calcium entry (SOCE) downstream of T cell receptor (TCR) activation in T lymphocytes has been shown to be mediated mainly through the Calcium Release Activated Calcium (CRAC) channel. Here, we compared the effects of a novel, potent and selective CRAC inhibitor, 2,6-Difluoro-N-{5-[4-m...
ORGANISM(S): Homo sapiens 
2013-01-31 | E-GEOD-43210 | biostudies-arrayexpress
TranscriptomicsGene expression comparison of post-sepsis versus naïve mice-derived tumor associated macrophages
To compare tumor associated macrophage (TAM) from naïve and sepsis surviving mice we have employed Agilent microarrays slides with almost 60,000 genes (39,430 mRNA and 16,251 long non coding RNAs). Other experiments we conducted demonstrated TAM accumulation was increased in post-sepsis subjects. Fo...
ORGANISM(S): Mus musculus 
2014-12-25 | E-GEOD-64498 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human SUM44 and LCCTam cells reveals ERRgamma mediates Tamoxifen resistance in novel models of invasive lobular breast cancer
One-third of all ER+ breast tumors treated with endocrine therapy fail to respond, and the remainder are likely to relapse in the future. Almost all data on endocrine resistance has been obtained in models of invasive ductal carcinoma (IDC). However, invasive lobular carcinomas (ILC) comprise up to...
ORGANISM(S): Homo sapiens 
2008-11-13 | E-GEOD-12708 | biostudies-arrayexpress
Sort   by:  
 Page size