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TranscriptomicsRNAi knock down of known nonsense-mediated mRNA decay (NMD) factors in Drosophila cells
All eukaryotes studied to date have the capacity to detect and degrade mRNAs harboring premature translation termination codons (PTCs) in a process called nonsense-mediated mRNA decay (NMD) (reviewed in Wagner E & Lykke-Andersen J, 2002). This surveillance system allows the cell to prevent the expre...
ORGANISM(S): Drosophila melanogaster 
2005-11-01 | E-MEXP-202 | biostudies-arrayexpress
TranscriptomicsHuman Nonsense-Mediated RNA Decay Initiates Widely by Endonucleolysis and Targets snoRNA Host Genes
Eukaryotic RNAs with premature termination codons (PTCs) are eliminated by nonsense-mediated decay (NMD). While human nonsense RNA degradation can be initiated either by an endonucleolytic cleavage event near the PTC or through decapping, the individual contribution of these activities on endogenous...
ORGANISM(S): Homo sapiens 
2014-11-18 | E-GEOD-57433 | biostudies-arrayexpress
UnknownIdentification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay.
Not available
S-EPMC134073 | biostudies-literature
UnknownCompetition between maturation and degradation drives human snRNA 3' end quality control.
Not available
S-EPMC7328512 | biostudies-literature
UnknownTailer: a pipeline for sequencing-based analysis of nonpolyadenylated RNA 3' end processing.
Not available
S-EPMC9014879 | biostudies-literature
UnknownAn unconventional human Ccr4-Caf1 deadenylase complex in nuclear cajal bodies.
Not available
S-EPMC1820451 | biostudies-literature
UnknownHyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay.
Not available
S-EPMC4987530 | biostudies-literature
UnknownhnRNP F complexes with tristetraprolin and stimulates ARE-mRNA decay.
Not available
S-EPMC4076271 | biostudies-literature
UnknownA competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay.
Not available
S-EPMC2689706 | biostudies-literature
UnknownAlternative splicing of the ADAR1 transcript in a region that functions either as a 5'-UTR or an ORF.
Not available
S-EPMC1986812 | biostudies-literature
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