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MetabolomicsDesorption electrospray ionisation mass spectrometry imaging of esophageal lymph mode metastases
Lymph node metastases (LNM) and primary tumour samples were analysed using desorption electrospray ionisation mass spectrometry imaging (DESI MSI). Current assessment of LNM depends on subjective histopathological assessment, whereas analysis by DESI MSI permits an entirely objective assessment. The...
2017-01-10 | MTBLS385 | MetaboLights
TranscriptomicsDecreased expression of key tumour suppressor microRNAs is associated with lymph node metastases in triple negative breast cancer
Breast cancer is the most common malignancy that develops in women, responsible for the highest cancer-associated death rates. Triple negative breast cancers (TNBC) represent an important subtype that have an aggressive clinical phenotype, are associated with a higher likelihood of metastasis and ar...
ORGANISM(S): Homo sapiens 
2014-11-24 | E-GEOD-38167 | biostudies-arrayexpress
TranscriptomicsLymph node transcriptional profiling
Endobronchial ultrasound (EBUS) guided biopsy is becoming the mainstay for investigation of mediastinal lymphadenopathy to aid laboratory diagnosis of malignancy, sarcoidosis or tuberculosis. However, diagnostic uncertainty is still common in the distinction between culture negative tuberculosis and...
ORGANISM(S): Homo sapiens 
2016-01-06 | E-MTAB-2547 | biostudies-arrayexpress
TranscriptomicsscRNA-seq of lymph node of mice where Cip2a locus has been disrupted and wild-type control mice at the peak of Experimental Autoimmune Encephalomyelis
We induced EAE in mice carrying a gene-trap disruption of Cip2a (hereafter referred to as knockout [KO] mice) and wild-type (WT) control C57BL/6J male and female mice, aged 8-12 weeks. We performed scRNA-seq analysis of lymph node cells from five WT and five KO mice at the peak of EAE. The goal was ...
ORGANISM(S): Mus musculus 
2026-09-30 | E-MTAB-17644 | biostudies-arrayexpress
TranscriptomicsComparison of lymph node negative (N0) and lymph node metastasis (N+) head and neck squamous-cell carcinomas (HNSCC)
A classifier was build on 82 training samples to differentiate between lymph node negative (N0) and lymph node metastasis (N+) head and neck squamous-cell carcinomas (HNSCC). The 102 predictor genes that resulted from this classifier where then validated against a independent validation set.
ORGANISM(S): Homo sapiens 
2005-01-09 | E-UMCU-11 | biostudies-arrayexpress
TranscriptomicsImmune and tumor cell gene expression from node positive and node negative breast cancers' primary tumor, lymph nodes and peripheral blood
Analysis of purified immune and breast tumor cells from three major compartments where cancer and immune cells interact: primary tumor, tumor draining lymph nodes (tumor invaded or tumor free), and peripheral blood. The results suggests that node-positive patients’ immune regulation and functionali...
ORGANISM(S): Homo sapiens 
2013-01-11 | E-GEOD-41986 | biostudies-arrayexpress
TranscriptomicsTranscriptomic survey of lymph node-positive vs. - negative ductal breast cancer
Lymph node involvement is a major prognostic variable in breast cancer. Whether the molecular mechanisms that drive breast cancer cells to colonize lymph nodes are shared with their capacity to form distant metastases is yet to be established. In a transcriptomic survey aimed at identifying molecula...
ORGANISM(S): Homo sapiens 
2013-03-05 | E-GEOD-44408 | biostudies-arrayexpress
MetabolomicsSimultaneous targeting of PD-1 and IL2Rβγ with radiation therapy to inhibit pancreatic cancer growth and metastasis - mouse spleen and lymph node T-cell metabolomics
Not available
ORGANISM(S): Mus musculus 
ST002487 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of matching human primary head and neck squamous cell carcinomas and cervical lymph node metastases.
An experiment was performed to investigate the perservation of gene expression upon metastasis of primary head and neck squamous cell carcinomas to the cervical lymph node.
ORGANISM(S): Homo sapiens 
2006-10-23 | E-TABM-114 | biostudies-arrayexpress
TranscriptomicsPrediction of lymph node involvement in breast cancer from primary tumor tissue using gene expression profiling and miRNAs.
Lymph node involvement is the most important prognostic factor in breast cancer, but little is known about the underlying molecular changes. First, to identify a molecular signature associated with nodal metastasis, gene expression analysis was performed on a homogeneous group of 96 primary breast t...
ORGANISM(S): Homo sapiens 
2011-02-04 | E-GEOD-23177 | biostudies-arrayexpress
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