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ProteomicsFollicle-like niches outside the cortex? 3D phase-contrast µCT revealed medullary B cell nodules in mucosa-draining lymph nodes
This study identifies and characterizes previously unrecognized medullary B cell niches within murine mucosa-draining lymph nodes (LNs), challenging the conventional understanding of LN architecture. Utilizing advanced imaging techniques, including synchrotron radiation-based phase-contrast micro-co...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-22 | PXD066656 | Pride
Lymph node niches  mucosal immunity  high endothelial venule (hev)  x-ray microtomography  aging  b cell microenvironment  lymphocyte homing  medulla 
TranscriptomicsSpatial transcriptomics from murine inguinal and mesenteric lymph nodes
B cell-interacting reticular cells (BRC) form transcriptionally and topologically stable immune-interacting microenvironments that direct efficient humoral immunity. While several immune niche factors have been elucidated, the cues sustaining BRC function and topology across activation states remain...
ORGANISM(S): Mus musculus 
2023-03-29 | E-MTAB-12468 | biostudies-arrayexpress
TranscriptomicsGEX: Single-cell RNA sequencing of human steady-state immune cells from the lamina propria of colon and matching mesenteric lymph nodes
The human colon contains an extensively diverse microbial ecosystem and one of the most numerous communities of immune cells. Studies have highlighted dynamic crosstalk between immune cells and commensals. While studies have demonstrated increasing diversity of microbiota from stomach to stool, whe...
ORGANISM(S): Homo sapiens 
2020-01-01 | E-MTAB-8474 | biostudies-arrayexpress
TranscriptomicsSingle cell RNAseq of fibroblastic reticular cells from mesenteric and inguinal murine lymph nodes at different developmental stages
Lymph nodes (LNs) are essential hubs for the induction and regulation of immune responses. Immune activation, either systemic or local, is accompanied by the lymph node swelling response, which results in up to threefold expansion in volume. Increased immigration of immune cells via the blood vascul...
ORGANISM(S): Mus musculus 
2025-11-11 | E-MTAB-13891 | biostudies-arrayexpress
ProteomicsLocal immunosuppression of tumor-draining lymph nodes via fibroblast-monocyte axis contributes to metastasis in breast cancer
Triple-negative breast cancer is the most aggressive form of breast cancer. Despite improvements in neoadjuvant treatment with immune checkpoint blockade targeting PD-1, response rates vary, and patients relapse with metastatic disease. Here, we show that immunosuppressive monocytes recruited via fi...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-14 | PXD066773 | Pride
Breast cancer Secretomes Dia Mouse Interstitial fluid Metastasis 
UnknownTargeting Lymph Node Niches Enhances Type 1 Immune Responses to Immunization.
Not available
S-EPMC7369031 | biostudies-literature
TranscriptomicsSingle cell RNAseq of immune and stromal cells from human lymph nodes
B cell-interacting reticular cells (BRC) form transcriptionally and topologically stable immune-interacting microenvironments that direct efficient humoral immunity. While several immune niche factors have been elucidated, the cues sustaining BRC function and topology across activation states remain...
ORGANISM(S): Homo sapiens 
2023-03-30 | E-MTAB-11710 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing of human steady-state immune cells from the lamina propria of colon and matching mesenteric lymph nodes
The human colon contains an extensively diverse microbial ecosystem and one of the most numerous communities of immune cells. Studies have highlighted dynamic crosstalk between immune cells and commensals. While studies have demonstrated increasing diversity of microbiota from stomach to stool, whe...
ORGANISM(S): Homo sapiens 
2020-01-01 | E-MTAB-8007 | biostudies-arrayexpress
TranscriptomicsSS2_2: Single-cell RNA sequencing of human steady-state immune cells from the lamina propria of colon and matching mesenteric lymph nodes
The human colon contains an extensively diverse microbial ecosystem and one of the most numerous communities of immune cells. Studies have highlighted dynamic crosstalk between immune cells and commensals. While studies have demonstrated increasing diversity of microbiota from stomach to stool, whe...
ORGANISM(S): Homo sapiens 
2020-01-01 | E-MTAB-8486 | biostudies-arrayexpress
TranscriptomicsSS2_1: Single-cell RNA sequencing of human steady-state immune cells from the lamina propria of colon and matching mesenteric lymph nodes
The human colon contains an extensively diverse microbial ecosystem and one of the most numerous communities of immune cells. Studies have highlighted dynamic crosstalk between immune cells and commensals. While studies have demonstrated increasing diversity of microbiota from stomach to stool, whe...
ORGANISM(S): Homo sapiens 
2020-01-01 | E-MTAB-8484 | biostudies-arrayexpress
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