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ProteomicsTCR targeting of KRAS G12V/C neoantigens is enhanced by lymphodepleting chemotherapy
Lung cancer remains the leading cause of cancer-related deaths worldwide. Immunotherapy agents have doubled treatment response rates in non-small cell lung cancer (NSCLC). However, these responses are neither universal nor consistently durable, underscoring the need for innovative therapeutic strate...
ORGANISM(S): Homo sapiens (Human) 
2025-10-03 | PXD061178 | Pride
Lymphodepleting chemotherapy Lung cancer Kras g12v Kras g12c Tcr therapy Neoantigens Colon cancer. Adoptive cell therapy Pancreatic cancer 
ProteomicsLymphodepleting chemotherapy potentiates neoantigen-directed T-cell therapy by enhancing antigen presentation
Adoptive cell therapy (ACT) targeting tumor-specific antigens holds promise for solid-tumors, but limited neoantigen presentation remains a key barrier to efficacy. Here, we identify and characterize a T-cell receptor (TCR), T104, for the KRAS.G12V mutation, a prevalent neoantigen in colorectal, lun...
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD070607 | Pride
Kras g12v Lymphodepleting chemotherapy Proteomics Kras g12c Tcr therapy Neoantigens Colon cancer. Adoptive cell therapy Immunotheraphy Pancreatic cancer 
GenomicsGenome-wide RNA sequencing on myeloid derived suppressor cells from mice treated with lymphodepleting chemotherapy
Genome-wide RNA sequencing on myeloid derived suppressor cells from mice treated with lymphodepleting chemotherapy
PRJNA562713 | ENA
UnknownReactive Myelopoiesis Triggered by Lymphodepleting Chemotherapy Limits the Efficacy of Adoptive T Cell Therapy.
Not available
S-EPMC7544980 | biostudies-literature
UnknownLymphodepleting chemotherapy potentiates neoantigen-directed T cell therapy by enhancing antigen presentation.
Not available
S-EPMC12765948 | biostudies-literature
GenomicsGenome-wide RNA sequencing on myeloid derived suppressor cells from mice treated with lymphodepleting chemotherapy reveals distinct IL-6 driven regulatory patterns
Genome-wide RNA sequencing on myeloid derived suppressor cells from mice treated with lymphodepleting chemotherapy reveals distinct IL-6 driven regulatory patterns
PRJNA562907 | ENA
UnknownAdenovirus Coding for Interleukin-2 and Tumor Necrosis Factor Alpha Replaces Lymphodepleting Chemotherapy in Adoptive T Cell Therapy.
Not available
S-EPMC6127851 | biostudies-literature
TranscriptomicsGenome-wide RNA sequencing on myeloid derived suppressor cells from mice treated with lymphodepleting chemotherapy
Myeloid derived suppressor cells (MDSCs) were sorted from B16 tumor-bearing mice that were untreated or given lymphodepleting cyclophosphamide and fludarbine. We report that monocytic and polymorphonuclear MDSC subsets (M-MDSCs and PMN-MDSCs respectively) have a unique gene expression profile in com...
ORGANISM(S): Mus musculus 
2020-07-03 | GSE136574 | GEO
UnknownSuccessful remission rates and survival after lymphodepleting chemotherapy and donor lymphocyte infusion for relapsed hematologic malignancies postallogeneic hematopoietic cell transplantation.
Not available
S-EPMC4107638 | biostudies-literature
GenomicsImmune checkpoint blockade augments lymphodepleting chemotherapy-induced antitumor immunity by expanding effector CD8+ T cell clones in preclinical models of cancer
Immune checkpoint blockade augments lymphodepleting chemotherapy-induced antitumor immunity by expanding effector CD8+ T cell clones in preclinical models of cancer
PRJNA1320634 | ENA
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