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TranscriptomicsThe basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor
Innate lymphoid cells (ILCs) are recently identified lymphocytes that limit infection and promote tissue repair at mucosal surfaces. However, the pathways underlying ILC development remain unclear. Here we show that the transcription factor NFIL3 directs the development of a committed bone marrow pr...
ORGANISM(S): Mus musculus 
2014-10-16 | E-GEOD-62337 | biostudies-arrayexpress
TranscriptomicsNovel Immunotherapy-Induced Tertiary Lymphoid Aggregates Accumulate as Intratumoral Nodal Structures of Immune Regulation in Pancreatic Cancer
Immunotherapy provides an alternative approach for cancer treatment. However, in-depth analyses of the effects of immunotherapy on the tumor microenvironment (TME) have not been conducted in non-melanoma tumors. Here we describe changes in the pancreatic ductal adenocarcinoma (PDAC) TME following i...
ORGANISM(S): Homo sapiens 
2014-08-05 | E-GEOD-52171 | biostudies-arrayexpress
TranscriptomicsThe transcription factor GATA3 is critical for the development of all IL-7Ra-expressing innate lymphoid cells (ILCs) and maintenance of type 2 ILCs
Innate lymphoid cells (ILCs) play critical roles during innate immune responses to pathogens and lymphoid organ development. IL-7Ra+ ILC subsets, similar to T helper (Th) cell subsets, produce distinctive effector cytokines. The molecular control of IL-7Ra+ ILC development and maintenance has yet to...
ORGANISM(S): Mus musculus 
2014-03-13 | E-GEOD-47851 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse lymphoid neoplasia shows changes in processing of 3 prime-UTR characterize clinically distinct tumor types
We used a novel probe-level microarray analysis, revealing connections between mRNA processing and lymphoid neoplasia, in a mouse leukemia model. Characteristic differences in mRNA processing, primarily in the 3’-untranslated region, distinguished histologically similar tumor subtypes with different...
ORGANISM(S): Mus musculus 
2009-10-16 | E-GEOD-15808 | biostudies-arrayexpress
UnknownReal Life Use of Bendamustine in Elderly Patients with Lymphoid Neoplasia.
Not available
S-EPMC8066290 | biostudies-literature
no omics definedTranscription profiling of wild type and Atm-/- mouse lymph nodes treated with ionizing radiation
The DNA damage response network modulates a wide array of signaling pathways, including DNA repair, cell cycle checkpoints, apoptotic pathways and numerous stress signals. The ATM protein kinase, functionally missing in patients with the human genetic disorder ataxia-telangiectasia (A-T), is a maste...
ORGANISM(S): Mus musculus 
2007-12-04 | E-GEOD-2118 | biostudies-arrayexpress
TranscriptomicsExpression of MALT1 oncogene in mouse hematopoietic stem/progenitor cells recapitulates the pathogenesis of human MALT lymphoma
Comparison of gene expression profiling analysis of bone marrow isolated CD34+ cells from patients with MALT lymphoma vs. healthy individuals revealed a large number of differentially expressed genes that included NF-kB target genes, genes involved in inflamatory signalling and immunoglobulin genes,...
ORGANISM(S): Homo sapiens 
2012-07-09 | E-GEOD-34015 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of murine innate lymphoid cells
Innate lymphoid cells (ILCs) are a recently recognized heterogenous group of immune cells that are critical in orchestrating immunity and inflammation in the intestine, but whether ILCs influence immune responses or tissue homeostasis at other mucosal sites remains poorly characterized. Here we iden...
ORGANISM(S): Mus musculus 
2013-04-30 | E-GEOD-46468 | biostudies-arrayexpress
TranscriptomicsDistinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1
Tyrosine kinase inhibitors (TKIs) directed against BCR-ABL1, the product of the Philadelphia (Ph) chromosome, have revolutionized treatment of patients with chronic myeloid leukemia (CML). However, acquired resistance to TKIs is a significant clinical problem in CML, and TKI therapy is much less eff...
ORGANISM(S): Mus musculus 
2016-01-17 | E-GEOD-75615 | biostudies-arrayexpress
UnknownKAP1 regulates gene networks controlling mouse B-lymphoid cell differentiation and function.
Not available
S-EPMC3683646 | biostudies-literature
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