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TranscriptomicsA Phase Two Randomised Controlled Trial of Belimumab in Kidney Transplant Recipients Demonstrates Comparable Safety, a Reduction in De Novo Antibody Production and an Increase in Regulatory B Cells.
There is an urgent unmet need in solid organ transplantation for immunotherapeutic strategies that target B cells and plasma cells, ideally without increasing infectious complications. We conducted a phase 2 double-blind randomised placebo-controlled trial to assess the safety and potential efficacy...
ORGANISM(S): Homo sapiens 
2018-06-11 | E-MTAB-5906 | biostudies-arrayexpress
UnknownPredictors of Cognitive Decline in Older Adult Type 2 Diabetes from the Veterans Affairs Diabetes Trial.
Not available
S-EPMC5015004 | biostudies-literature
UnknownTowards the objective assessment of suicidal states: Some neurocognitive deficits may be temporally related to suicide attempt.
Not available
S-EPMC7165019 | biostudies-literature
TranscriptomicsCoordinated regulation of synthesis and stability of RNA during the acute TNF-induced proinflammatory response
Steady-state gene expression is a coordination of synthesis and decay of RNA through epigenetic regulation, transcription factors, miRNAs, and RNA-binding proteins. Here, we present Bru-Seq and BruChase-Seq to assess genome-wide changes to RNA synthesis and stability in human fibroblasts at homeosta...
ORGANISM(S): Homo sapiens 
2013-01-29 | E-GEOD-43440 | biostudies-arrayexpress
UnknownSevere food allergy reactions are associated with α-tryptase.
Not available
S-EPMC10592152 | biostudies-literature
TranscriptomicsComparison of constitutional and replication stress-induced genome structural variation by SNP array and mate-pair sequencing
Copy number variants (CNVs) are a major source of genetic variation in human health and disease. Previous studies have suggested replication stress, such as that caused by the polymerase inhibitor aphidicolin, as a causative factor in CNV formation, but existing data are technically limited in the ...
ORGANISM(S): Homo sapiens 
2010-12-18 | E-GEOD-26121 | biostudies-arrayexpress
Genomicsena-DATASET-irgb_cnr-12-01-2017-10:08:18:724-1 - samples
List of SNPs, and their frequencies, extracted from a low pass whole genome sequencing of 3,514 individuals.
EGAD00001003141 | EGA
TranscriptomicsAplysia pleural Ganglia 1 Hour After Long-Term Sensitization Training
We used a custom-designed microarray and qPCR to characterize the rapid transcriptional response to long-term sensitization training in the marine mollusk Aplysia californica. Aplysia were exposed to repeated noxious shocks to one side of the body (4 ten-second shocks at 90mA, 30 min ISI), a proced...
ORGANISM(S): Aplysia californica 
2014-05-08 | E-GEOD-57458 | biostudies-arrayexpress
UnknownCHAMPION-1: a phase 1/2 study of once-weekly carfilzomib and dexamethasone for relapsed or refractory multiple myeloma.
Not available
S-EPMC4929927 | biostudies-literature
GenomicsWhole-genome low pass sequencing of 3,514 Sardinian individuals
The dataset includes the VCF files with the list of variants, and their frequency, found in 3,514 Sardinian individuals recruited from the SardiNIA longitudinal study (N=2090) and from a case-control study of autoimmune diseases in Sardinia (N=1424).
EGAS00001002212 | EGA
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