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ProteomicsCharacterization of proteome changes after 48 hours of TR-57 (ClpP agonist) treatment
ONC201 is a first-in-class, FDA approved small molecule activator of the mitochondrial ATP-dependent caseinolytic peptidase P (ClpP). This and other related small molecules referred to as ClpP agonists, exert antiproliferative effects in several cancer cell types. We report that ONC201 and highly p...
ORGANISM(S): Homo sapiens (Human) 
2026-09-21 | PXD067842 | Pride
Cell cycle arrest Mitochondrial metabolism Regulation of cell death Clpp agonist Dna damage Triple-negative breast cancer Senescence 
ProteomicsProtein-protein interaction network mapping for yeast PKA catalytic subunits using BioID
Paralogs engage in biological processes through both redundant and non-redundant functions. In yeast Saccharomyces cerevisiae, approximately one-fifth of the genome consists of paralogs, with their encoded proteins involved in multiple crucial pathways. However, the contributions of individual paral...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-09-28 | PXD067402 | Pride
Paralogs  glucose sensing  pka  protein-protein interaction  bioid  proteomics 
ProteomicsThe temporal effect of RMC-7977 treatment on the PANC-1 cell total proteome
KRAS-driven pancreatic ductal adenocarcinoma (PDAC) is dependent on nutrient scavenging pathways to fuel the metabolic demands of proliferation. While acute KRAS loss results in downregulated macropinocytosis, we observed that this downregulation is transient and returns to basal levels in the absen...
ORGANISM(S): Homo sapiens (Human) 
2026-06-25 | PXD066616 | Pride
Ras inhibitors Resistance Global proteomics Pancreatic cancer 
UnknownA randomized, double-blind, placebo-controlled phase 2 study evaluating the efficacy and safety of romiplostim treatment of patients with low or intermediate-1 risk myelodysplastic syndrome receiving lenalidomide.
Not available
S-EPMC3520696 | biostudies-literature
UnknownRadiosensitization In Vivo by Histone Deacetylase Inhibition with No Increase in Early Normal Tissue Radiation Toxicity.
Not available
S-EPMC5712223 | biostudies-literature
ProteomicsQuantitative chemical proteomic profiling of phosphoprotein phosphatases
We have developed a chemical proteomic strategy for the systematic interrogation of endogenous phosphoprotein phosphatases (PPP) and their interacting proteins, including regulatory and scaffolding subunits, and substrates (the 'PPPome'). PPPs are captured using an immobilized non-selective PPP inhi...
ORGANISM(S): Neurospora Crassa (ncbitaxon:5141) Candida Albicans (ncbitaxon:5476) Saccharomyces Cerevisiae (ncbitaxon:4932) Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) Schizosaccharomyces Pombe (ncbitaxon:4896) 
2017-07-07 | MSV000081226 | MassIVE
UnknownPredictors of Cognitive Decline in Older Adult Type 2 Diabetes from the Veterans Affairs Diabetes Trial.
Not available
S-EPMC5015004 | biostudies-literature
UnknownDynamics of SLC25A51 Reveal Preference for Oxidized NAD+ and Substrate Led Transport
Not available
S-SCDT-10_15252-EMBR_202256596 | biostudies-other
UnknownCarbon dioxide flushing versus saline flushing of thoracic aortic stents (INTERCEPTevar): protocol for a multicentre pilot randomised controlled trial.
Not available
S-EPMC10151986 | biostudies-literature
UnknownBi- and tri-valent T cell engagers deplete tumour-associated macrophages in cancer patient samples.
Not available
S-EPMC6873687 | biostudies-literature
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